HMGA2 as a critical regulator in cancer development
The high mobility group protein 2 (HMGA2) regulates gene expression by binding to AT-rich
regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in …
regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in …
Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues
Human papilloma viruses (HPV) are a small group of non‑enveloped viruses belonging to
the Papillomaviridae family with strong similarities to polyoma viruses. The viral particles …
the Papillomaviridae family with strong similarities to polyoma viruses. The viral particles …
[HTML][HTML] Patient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer
K Lõhmussaar, R Oka, JE Valle-Inclan, MHH Smits… - Cell Stem Cell, 2021 - cell.com
Cervical cancer is a common gynecological malignancy often caused by high-risk human
papillomavirus. There is a paucity of human-derived culture systems to study the cervical …
papillomavirus. There is a paucity of human-derived culture systems to study the cervical …
Enhanced radiation sensitivity in HPV-positive head and neck cancer
Patients with human papillomavirus (HPV+)–associated head and neck cancer (HNC) show
significantly improved survival outcome compared with those with HPV-negative (HPV−) …
significantly improved survival outcome compared with those with HPV-negative (HPV−) …
The emerging role of CXCL10 in cancer
The chemokine interferon-γ inducible protein 10 kDa (CXCL10) is a member of the CXC
chemokine family which binds to the CXCR3 receptor to exert its biological effects. CXCL10 …
chemokine family which binds to the CXCR3 receptor to exert its biological effects. CXCL10 …
Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene
Background: There is a need to develop robust and clinically applicable gene expression
signatures. Hypoxia is a key factor promoting solid tumour progression and resistance to …
signatures. Hypoxia is a key factor promoting solid tumour progression and resistance to …
Tumour-infiltrating lymphocytes predict response to definitive chemoradiotherapy in head and neck cancer
P Balermpas, Y Michel, J Wagenblast, O Seitz… - British journal of …, 2014 - nature.com
Background: We aimed to investigate the prognostic value of tumour-infiltrating
lymphocytes'(TILs) expression in pretreatment specimens from patients with head and neck …
lymphocytes'(TILs) expression in pretreatment specimens from patients with head and neck …
Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling
JA Den Boon, D Pyeon, SS Wang… - Proceedings of the …, 2015 - National Acad Sciences
To study the multistep process of cervical cancer development, we analyzed 128 frozen
cervical samples spanning normalcy, increasingly severe cervical intraepithelial neoplasia …
cervical samples spanning normalcy, increasingly severe cervical intraepithelial neoplasia …
The landscape of viral expression and host gene fusion and adaptation in human cancer
Abstract Viruses cause 10–15% of all human cancers. Massively parallel sequencing has
recently proved effective for uncovering novel viruses and virus–tumour associations, but …
recently proved effective for uncovering novel viruses and virus–tumour associations, but …
Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications
CH Chung, ML Gillison - Clinical cancer research, 2009 - AACR
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with
an annual incidence of approximately 400,000 worldwide. Although the principal risk factors …
an annual incidence of approximately 400,000 worldwide. Although the principal risk factors …