Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of
cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of …

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-
catenin controls embryonic development and adult homeostasis. Here we review recent …

Clostridium difficile toxin B (TcdB) is a critical virulence factor that causes diseases
associated with C. difficile infection. Here we carried out CRISPR–Cas9-mediated genome …

Wnt signaling transduces evolutionarily conserved pathways which play important roles in
initiating and regulating a diverse range of cellular activities, including cell proliferation …

GSK3 is one of the few signaling mediators that play central roles in a diverse range of
signaling pathways, including those activated by Wnts, hedgehog, growth factors, cytokines …

Wnts compromise a large family of secreted, hydrophobic glycoproteins that control a variety
of developmental and adult processes in all metazoan organisms. Recent advances in the …

The canonical Wnt/β-catenin pathway is an ancient and evolutionarily conserved signaling
pathway that is required for the proper development of all metazoans, from the basal …

The canonical Wnt signaling pathway (or Wnt/β-catenin pathway) plays a pivotal role in
embryonic development and adult homeostasis; deregulation of the Wnt pathway …

One of the early surprises in the study of cell adhesion was the discovery that β-catenin
plays dual roles, serving as an essential component of cadherin-based cell–cell adherens …

Low-density lipoprotein receptor related proteins 5 and 6 (LRP5/6) are transmembrane
receptors that initiate Wnt/β-catenin signaling. Phosphorylation of PPPSP motifs in the LRP6 …