Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Single agent checkpoint inhibitor therapy has not been effective for most gastrointestinal
solid tumors, but combination therapy with drugs targeting additional immunosuppressive …

Lipid rafts are tightly packed, cholesterol-and sphingolipid-enriched microdomains within the
plasma membrane that play important roles in many pathophysiologic processes. Rafts have …

Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

Gastric adenocarcinoma, even when diagnosed at an early (localized) disease stage, poses
a major health-care burden with cure rates that remain unsatisfactorily low, particularly in …

Background Mast cells are prominent components of solid tumors and exhibit distinct
phenotypes in different tumor microenvironments. However, the nature, regulation, function …

Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties that
sustain cancers, which may be responsible for cancer metastasis or recurrence. Lipid rafts …

Lipid rafts are critical cell membrane lipid platforms enriched in sphingolipid and cholesterol
content involved in diverse cellular processes. They have been proposed to influence …

Chemokines, a subfamily of the cell cytokines, are low molecular weight proteins known to
induce chemotaxis in leukocytes in response to inflammatory and pathogenic signals. A …

Aims Glioblastoma (GBM) with aggressive nature and poor prognosis has become the most
common intracranial tumor. Most clinical chemotherapeutic drugs fail to achieve the …