The most frequent cause of portal hypertension is liver cirrhosis, and many of lethal
complications of cirrhosis such as ascites and gastroesophageal variceal hemorrhage are …

Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics,
display remarkable heterogeneity in structure and function. This is the second of a 2-part …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …

Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on
cellular signal transduction and accumulating evidence indicates important roles for S …

Stimulation of cell-surface seven-transmembrane receptors (7TMRs) elicits biological
responses to a wide range of extracellular signals, including many hormones. Classically …

Heterotrimeric G protein–coupled receptors (GPCRs) are found on the surface of all cells of
multicellular organisms and are major mediators of intercellular communication. More than …

LSECs are a unique population of endothelial cells within the liver and are recognized as
key regulators of liver homeostasis. LSECs also play a key role in liver disease, as …

Background & Aims: Following hepatic injury, hepatic stellate cells (HSCs) transdifferentiate
to become extracellular matrix-producing myofibroblasts and to promote hepatic …

Drugs that act on dopamine neurotransmission are important tools for the management of
multiple neuropsychiatric disorders. Classically, dopamine receptors have been shown to …