Abstract Purpose of Review Our goal is to examine the processes—both central and
peripheral—that underlie the development of peripherally-induced neuropathic pain (pNP) …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

Sensory abnormalities generated by nerve injury, peripheral neuropathy or disease are
often expressed as neuropathic pain. This type of pain is frequently resistant to therapeutic …

Background Nerve injury may induce neuropathic pain. In studying the mechanisms of
orofacial neuropathic pain, attention has been paid to the plastic changes that occur in the …

Neuropathic pain often arises from damage to peripheral nerves and is difficult to treat.
Activation of opioid receptors in peripheral sensory neurons is devoid of respiratory …

Diabetic peripheral neuropathic pain (DPNP) is a distal spontaneous pain, caused by lesion
of sensory neurons and accompanied by depression and anxiety frequently, which reduce …

Background and Purpose Activation of GIRK channels via G protein‐coupled GABAB
receptors has been shown to attenuate nociceptive transmission. The analgesic α‐conotoxin …

Clinical and basic science research have revealed persistent effects of early-life injury on
nociceptive processing and resulting pain sensitivity. While recent work has identified clear …

The present study describes the discovery and characterization of a series of 5-aryl-2H-
tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels …

FRMD6, a member of the group of FERM-domain proteins, is involved both in
communication between cells, interactions with extracellular matrix, cellular apoptotic and …