Tumor angiogenesis and vascular normalization: alternative therapeutic targets

C Viallard, B Larrivée - Angiogenesis, 2017 - Springer
Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …

VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity

M Giannotta, M Trani, E Dejana - Developmental cell, 2013 - cell.com
VE-cadherin is a component of endothelial cell-to-cell adherens junctions, and it has a key
role in the maintenance of vascular integrity. During embryo development, VE-cadherin is …

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis

B Palikuqi, DHT Nguyen, G Li, R Schreiner… - Nature, 2020 - nature.com
Endothelial cells adopt tissue-specific characteristics to instruct organ development and
regeneration,. This adaptability is lost in cultured adult endothelial cells, which do not …

Molecular mechanisms and clinical applications of angiogenesis

P Carmeliet, RK Jain - Nature, 2011 - nature.com
Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish
diseases such as cancer. Over the past decade, our understanding of the molecular …

Basic and therapeutic aspects of angiogenesis

M Potente, H Gerhardt, P Carmeliet - Cell, 2011 - cell.com
Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel
growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and …

[HTML][HTML] Magnesium alloys for orthopedic applications: A review on the mechanisms driving bone healing

N Wang, S Yang, H Shi, Y Song, H Sun, Q Wang… - Journal of Magnesium …, 2022 - Elsevier
Magnesium (Mg) alloys have attracted a wealth of attention in orthopedic fields for their
superior mechanical properties, degradability, and excellent biocompatibility. Consistently …

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

SP Herbert, DYR Stainier - Nature reviews Molecular cell biology, 2011 - nature.com
The vertebrate vasculature forms an extensive branched network of blood vessels that
supplies tissues with nutrients and oxygen. During vascular development, coordinated …

Blood flow forces in shaping the vascular system: a focus on endothelial cell behavior

P Campinho, A Vilfan, J Vermot - Frontiers in physiology, 2020 - frontiersin.org
The endothelium is the cell monolayer that lines the interior of the blood vessels separating
the vessel lumen where blood circulates, from the surrounding tissues. During embryonic …

Developmental and pathological angiogenesis

AS Chung, N Ferrara - Annual review of cell and developmental …, 2011 - annualreviews.org
The formation of the vascular network is an intricate and complex process that is an obligate
requirement during vertebrate development. The cardiovascular system is the first organ to …

Targeting the tumour vasculature: insights from physiological angiogenesis

AS Chung, J Lee, N Ferrara - Nature reviews cancer, 2010 - nature.com
The cardiovascular system ensures the delivery of nutrients, oxygen, and blood and immune
cells to all organs and tissues: it is also responsible for the removal of waste metabolites …