Pre-eclampsia: pathogenesis, novel diagnostics and therapies

EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …

[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

Combining biomarkers to predict pregnancy complications and redefine preeclampsia: the angiogenic-placental syndrome

H Stepan, M Hund, T Andraczek - Hypertension, 2020 - Am Heart Assoc
Placental dysfunction underlies a spectrum of perinatal pathologies, including preeclampsia
and fetal growth restriction. Angiogenesis-related factors, including sFlt-1 (soluble fms-like …

Preeclampsia: novel mechanisms and potential therapeutic approaches

Z Armaly, JE Jadaon, A Jabbour, ZA Abassi - Frontiers in physiology, 2018 - frontiersin.org
Preeclampsia is a serious complication of pregnancy where it affects 5–8% of all
pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman …

Meta-analysis and systematic review to assess the role of soluble FMS-like tyrosine kinase-1 and placenta growth factor ratio in prediction of preeclampsia: the …

S Agrawal, AS Cerdeira, C Redman, M Vatish - Hypertension, 2018 - Am Heart Assoc
Preeclampsia is a major cause of morbidity and mortality worldwide. Numerous candidate
biomarkers have been proposed for diagnosis and prediction of preeclampsia …

A literature review and best practice advice for second and third trimester risk stratification, monitoring, and management of pre‐eclampsia: Compiled by the …

LC Poon, LA Magee, S Verlohren… - … of Gynecology & …, 2021 - Wiley Online Library
Pre-eclampsia is a multisystem disorder that typically affects 2%–5% of pregnant women
and is one of the leading causes of maternal and perinatal morbidity and mortality …

A maternal serum metabolite ratio predicts fetal growth restriction at term

U Sovio, N Goulding, N McBride, E Cook, F Gaccioli… - Nature medicine, 2020 - nature.com
Fetal growth restriction (FGR) is the major single cause of stillbirth and is also associated
with neonatal morbidity and mortality,, impaired health and educational achievement in …

Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia

S Tong, J Tu'uhevaha, R Hastie, F Brownfoot… - American journal of …, 2022 - Elsevier
There has been increasing research momentum to identify new therapeutic agents for the
prevention or treatment of preeclampsia, drugs that can affect the underlying disease …

Screening for fetal growth restriction using ultrasound and the sFLT1/PlGF ratio in nulliparous women: a prospective cohort study

F Gaccioli, U Sovio, E Cook, M Hund… - The Lancet Child & …, 2018 - thelancet.com
Background Fetal growth restriction is a major determinant of perinatal morbidity and
mortality. This condition has no gold standard definition, but a widely used proxy is delivery …

[HTML][HTML] Clinical interpretation and implementation of the sFlt-1/PlGF ratio in the prediction, diagnosis and management of preeclampsia

S Verlohren, SP Brennecke, A Galindo… - Pregnancy …, 2022 - Elsevier
Preeclampsia is associated with significant morbidity and mortality for mother and baby.
Although around 30% of all pregnancies are evaluated for preeclampsia, diagnosis is …