Wnt signaling in colorectal cancer: pathogenic role and therapeutic target

H Zhao, T Ming, S Tang, S Ren, H Yang, M Liu, Q Tao… - Molecular cancer, 2022 - Springer
Abstract Background The Wnt signaling pathway is a complex network of protein interactions
that functions most commonly in embryonic development and cancer, but is also involved in …

Transcriptional regulation of Wnt/β-catenin pathway in colorectal cancer

J Bian, M Dannappel, C Wan, R Firestein - Cells, 2020 - mdpi.com
The Wnt/β-catenin signaling pathway exerts integral roles in embryogenesis and adult
homeostasis. Aberrant activation of the pathway is implicated in growth-associated diseases …

Association of the epithelial–mesenchymal transition (EMT) with cisplatin resistance

M Ashrafizadeh, A Zarrabi, K Hushmandi… - International journal of …, 2020 - mdpi.com
Therapy resistance is a characteristic of cancer cells that significantly reduces the
effectiveness of drugs. Despite the popularity of cisplatin (CP) as a chemotherapeutic agent …

MACC1 promotes pancreatic cancer metastasis by interacting with the EMT regulator SNAI1

X Zhang, Y Luo, Y Cen, X Qiu, J Li, M Jie, S Yang… - Cell Death & …, 2022 - nature.com
Metastasis is the dominant cause of cancer-related mortality. Metastasis-associated with
colon cancer protein 1 (MACC1) has been proven to play a critical role in cancer metastasis …

[HTML][HTML] Research advances in endometriosis-related signaling pathways: a review

M Zhang, T Xu, D Tong, S Li, X Yu, B Liu, L Jiang… - Biomedicine & …, 2023 - Elsevier
Endometriosis (EM) is characterized by the existence of endometrial mucosa outside the
uterine cavity, which causesinfertility, persistent aches, and a decline in women's quality of …

Endometrial epithelial cells-derived exosomes deliver microRNA-30c to block the BCL9/Wnt/CD44 signaling and inhibit cell invasion and migration in ovarian …

M Zhang, X Wang, X Xia, X Fang, T Zhang… - Cell Death …, 2022 - nature.com
Endometriosis (EMs) is a benign gynecological disorder showing some tumor-like migratory
and invasive phenotypes. This study intended to investigate the role of microRNA-30c (miR …

Clinical validation of a machine-learning–derived signature predictive of outcomes from first-line oxaliplatin-based chemotherapy in advanced colorectal cancer

JP Abraham, D Magee, C Cremolini, C Antoniotti… - Clinical Cancer …, 2021 - AACR
Abstract Purpose: FOLFOX, FOLFIRI, or FOLFOXIRI chemotherapy with bevacizumab is
considered standard first-line treatment option for patients with metastatic colorectal cancer …

Angiogenesis-related functions of Wnt signaling in colorectal carcinogenesis

A Kasprzak - Cancers, 2020 - mdpi.com
Simple Summary Angiogenesis belongs to the most clinical characteristics of colorectal
cancer (CRC) and is strongly linked to the activation of Wnt/β-catenin signaling. The most …

The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis

V Vafaizadeh, D Buechel, N Rubinstein, RKR Kalathur… - Oncogene, 2021 - nature.com
Canonical Wnt/β-catenin signaling is an established regulator of cellular state and its critical
contributions to tumor initiation, malignant tumor progression and metastasis formation have …

[HTML][HTML] Human cancer cells generate spontaneous calcium transients and intercellular waves that modulate tumor growth

C Liang, Q Zhang, X Chen, J Liu, M Tanaka, S Wang… - Biomaterials, 2022 - Elsevier
Electrically excitable cells such as neurons transmit long-distance calcium or electrical
signals to regulate their physiological functions. While the molecular underpinnings and …