Simple Summary This review provides an overview of the state of knowledge and general
understanding of CDK inhibitors currently under development or clinically approved, with a …

Many cancer therapies aim to trigger apoptosis in cancer cells. Nevertheless, the presence
of oncogenic alterations in these cells and distorted composition of tumour …

Objectives In this study we describe the tumor microenvironment, the signaling pathways
and genetic alterations associated with the presence or absence of CD8+ T-cell infiltration in …

Colorectal cancer (CRC) is a common gastrointestinal malignancy, and recurrence and
metastasis contribute considerably to its high mortality. It is well known that the epithelial …

Background Cuproptosis is a novel form of cell death that is highly related to mitochondrial
metabolism and mediated by protein lipoacetylation. This study systematically assessed the …

Therapeutic innovation for human papilloma virus‐related (HPV+) head and neck squamous
cell carcinomas (HNSCCs) is impaired by inadequate preclinical models and the absence of …

Aging is regarded as a dominant risk factor for cancer. Additionally, inflammation and
asthenic immune surveillance with aging may facilitate tumor formation and development …

Genomic alterations are a driving force in the multistep process of head and neck cancer
(HNC) and result from the interaction of exogenous environmental exposures and …

Head and neck squamous cell carcinoma (HNSCC), the most common malignancy of the
head and neck, has an overall 5-year survival rate of< 50%. Genes associated with …

Head and neck squamous cell carcinoma (HNSCC) shows wide disparities, association with
human papillomavirus (HPV) infection, and prognosis. We aimed at determining HPV …