Gliomas, the most common malignant primary brain tumours, remain universally lethal. Yet,
seminal discoveries in the past 5 years have clarified the anatomy, genetics and function of …

Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous
system. Due to the absence of effective pharmacological and surgical treatments, the …

Background Nearly all patients with newly diagnosed glioblastoma experience recurrence
following standard-of-care radiotherapy (RT)+ temozolomide (TMZ). The purpose of the …

Eighty percent of all malignant primary brain tumors diagnosed in the United States are
gliomas. 1 The current treatment paradigm for high-grade gliomas (grades III and IV) …

Humans are exposed to a complex mix of man-made electric and magnetic fields (MFs) at
many different frequencies, at home and at work. Epidemiological studies indicate that there …

Objective Summarize evidence for use of advanced MRI techniques as monitoring
biomarkers in the clinic, and highlight the latest bench-to-bedside developments. Methods …

Immunotherapy has become a fourth pillar in the treatment of brain tumors and, when
combined with radiation therapy, may improve patient outcomes and reduce the …

Background Therapeutic options are limited in pediatric CNS malignancies. CheckMate 908
(NCT03130959) is an open-label, sequential-arm, phase 1b/2 study investigating nivolumab …

Magnetic resonance imaging is integral to the care of patients with high-grade gliomas.
Anatomic detail can be acquired with conventional structural imaging, but newer …

Simple Summary The optimal treatment and management of patients with brain cancer
depend on the molecular characteristics of their tumour. Since the tumour changes with time …