[HTML][HTML] Targeting mTOR for cancer therapy
H Hua, Q Kong, H Zhang, J Wang, T Luo… - Journal of hematology & …, 2019 - Springer
Mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival,
metabolism, and immunity. mTOR is usually assembled into several complexes such as …
metabolism, and immunity. mTOR is usually assembled into several complexes such as …
[HTML][HTML] Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
MA Feitelson, A Arzumanyan, RJ Kulathinal… - Seminars in cancer …, 2015 - Elsevier
Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …
PI3K and cancer: lessons, challenges and opportunities
DA Fruman, C Rommel - Nature reviews Drug discovery, 2014 - nature.com
The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …
[HTML][HTML] Regulation of mammary stem/progenitor cells by PTEN/Akt/β-catenin signaling
Recent evidence suggests that many malignancies, including breast cancer, are driven by a
cellular subcomponent that displays stem cell-like properties. The protein phosphatase and …
cellular subcomponent that displays stem cell-like properties. The protein phosphatase and …
Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling
Cognitive impairment is one of the most important negative consequences associated with
cannabis consumption. We found that CB1 cannabinoid receptor (CB1R) activation …
cannabis consumption. We found that CB1 cannabinoid receptor (CB1R) activation …
Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling
In this review we discuss current findings in the human skeletal muscle literature describing
the acute influence of nutrients (leucine-enriched essential amino acids in particular) and …
the acute influence of nutrients (leucine-enriched essential amino acids in particular) and …
[HTML][HTML] Are Wnt/β-catenin and PI3K/AKT/mTORC1 distinct pathways in colorectal cancer?
A Prossomariti, G Piazzi, C Alquati… - Cellular and molecular …, 2020 - Elsevier
Wnt/β-catenin and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of
rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in …
rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in …
[HTML][HTML] Mnk kinase pathway: Cellular functions and biological outcomes
S Joshi, LC Platanias - World journal of biological chemistry, 2014 - ncbi.nlm.nih.gov
The mitogen-activated protein kinase (MAPK) interacting protein kinases 1 and 2 (Mnk1 and
Mnk2) play important roles in controlling signals involved in mRNA translation. In addition to …
Mnk2) play important roles in controlling signals involved in mRNA translation. In addition to …
The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
AS Green, N Chapuis, T Trovati Maciel… - Blood, The Journal …, 2010 - ashpublications.org
Finding an effective treatment for acute myeloid leukemia (AML) remains a challenge, and
all cellular processes that are deregulated in AML cells should be considered in the design …
all cellular processes that are deregulated in AML cells should be considered in the design …
Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development
MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine
kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap …
kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap …