Mesenchymal stromal cell homing: mechanisms and strategies for improvement

M Ullah, DD Liu, AS Thakor - Iscience, 2019 - cell.com
Mesenchymal stromal cells (MSCs) have been widely investigated for their therapeutic
potential in regenerative medicine, owing to their ability to home damaged tissue and serve …

Atherosclerosis and inflammation: insights from the theory of general pathological processes

E Gusev, A Sarapultsev - International Journal of Molecular Sciences, 2023 - mdpi.com
Recent advances have greatly improved our understanding of the molecular mechanisms
behind atherosclerosis pathogenesis. However, there is still a need to systematize this data …

Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice

B Yu, H Li, Z Zhang, P Chen, L Wang, X Fan… - Nature …, 2023 - nature.com
Extracellular vesicles have shown good potential in disease treatments including ischemic
injury such as myocardial infarction. However, the efficient production of highly active …

Inflammatory chemokines in atherosclerosis

S Gencer, BR Evans, EPC van der Vorst, Y Döring… - Cells, 2021 - mdpi.com
Atherosclerosis is a long-term, chronic inflammatory disease of the vessel wall leading to the
formation of occlusive or rupture-prone lesions in large arteries. Complications of …

[HTML][HTML] Challenges and strategies for in situ endothelialization and long-term lumen patency of vascular grafts

Y Zhuang, C Zhang, M Cheng, J Huang, Q Liu… - Bioactive Materials, 2021 - Elsevier
Vascular diseases are the most prevalent cause of ischemic necrosis of tissue and organ,
which even result in dysfunction and death. Vascular regeneration or artificial vascular graft …

Pathophysiology and immune dysfunction in endometriosis

SH Ahn, SP Monsanto, C Miller… - BioMed research …, 2015 - Wiley Online Library
Endometriosis is an estrogen‐dependent, chronic, proinflammatory disease prevalent in
10% of women of reproductive age worldwide. Characterized by the growth of endometrium …

Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions

SK Sanganalmath, R Bolli - Circulation research, 2013 - Am Heart Assoc
Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …

Response of the cerebral vasculature following traumatic brain injury

A Salehi, JH Zhang, A Obenaus - Journal of Cerebral Blood …, 2017 - journals.sagepub.com
The critical role of the vasculature and its repair in neurological disease states is beginning
to emerge particularly for stroke, dementia, epilepsy, Parkinson's disease, tumors and …

Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing

G Chamberlain, J Fox, B Ashton, J Middleton - Stem cells, 2007 - academic.oup.com
MSCs are nonhematopoietic stromal cells that are capable of differentiating into, and
contribute to the regeneration of, mesenchymal tissues such as bone, cartilage, muscle …

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

DJ Ceradini, AR Kulkarni, MJ Callaghan, OM Tepper… - Nature medicine, 2004 - nature.com
The trafficking of circulating stem and progenitor cells to areas of tissue damage is poorly
understood. The chemokine stromal cell–derived factor-1 (SDF-1 or CXCL12) mediates …