The effects of type 2 diabetes mellitus on organ metabolism and the immune system

G Daryabor, MR Atashzar, D Kabelitz, S Meri… - Frontiers in …, 2020 - frontiersin.org
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …

Type 2 Diabetes Mellitus and Altered Immune System Leading to Susceptibility to Pathogens, Especially Mycobacterium tuberculosis

S Ferlita, A Yegiazaryan, N Noori, G Lal… - Journal of clinical …, 2019 - mdpi.com
There has been an alarming increase in the incidence of Type 2 Diabetes Mellitus (T2DM)
worldwide. Uncontrolled T2DM can lead to alterations in the immune system, increasing the …

Diabetes and tuberculosis

BI Restrepo - Understanding the host immune response against …, 2018 - Springer
The worldwide increase in the prevalence of diabetes has been most notable in TB-endemic
countries and has led to the re-emerging importance of the association between these two …

Influence of diabetes mellitus on immunity to human tuberculosis

P Kumar Nathella, S Babu - Immunology, 2017 - Wiley Online Library
Type 2 diabetes mellitus (DM) is a major risk factor for the development of active pulmonary
tuberculosis (TB), with development of DM pandemic in countries where TB is also endemic …

Immunological mechanisms contributing to the double burden of diabetes and intracellular bacterial infections

K Hodgson, J Morris, T Bridson, B Govan, C Rush… - …, 2015 - Wiley Online Library
Diabetes has been recognized as an important risk factor for a variety of intracellular
bacterial infections, but research into the dysregulated immune mechanisms contributing to …

Diabetes and immunity to tuberculosis

N Martinez, H Kornfeld - European journal of immunology, 2014 - Wiley Online Library
The dual burden of tuberculosis (TB) and diabetes has attracted much attention in the past
decade as diabetes prevalence has increased dramatically in countries already afflicted with …

Indole propionic acid, an unusual antibiotic produced by the gut microbiota, with anti-inflammatory and antioxidant properties

DA Negatu, M Gengenbacher, V Dartois… - Frontiers in …, 2020 - frontiersin.org
Most antibiotics are produced by soil microbes and typically interfere with macromolecular
synthesis processes as their antibacterial mechanism of action. These natural products are …

Human immunology of tuberculosis

TJ Scriba, AK Coussens, HA Fletcher - Microbiology spectrum, 2017 - Am Soc Microbiol
Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human
infection with Mycobacterium tuberculosis is dependent on the ability of the immune …

Systems immunology of diabetes-tuberculosis comorbidity reveals signatures of disease complications

CA Prada-Medina, KF Fukutani, N Pavan Kumar… - Scientific reports, 2017 - nature.com
Comorbid diabetes mellitus (DM) increases tuberculosis (TB) risk and adverse outcomes but
the pathological interactions between DM and TB remain incompletely understood. We …

Diabetic lung disease: fact or fiction?

S Kolahian, V Leiss, B Nürnberg - Reviews in Endocrine and Metabolic …, 2019 - Springer
Diabetes mellitus is a chronic, progressive, incompletely understood metabolic disorder
whose prevalence has been increasing steadily worldwide. Even though little attention has …