Atherosclerosis is the most common form of vascular disease and constitutes the major
cause of death, with 17.5 million related deaths annually (31% of global mortality). 1 …

Advances in atherosclerosis imaging technology and research have provided a range of
diagnostic tools to characterize high-risk plaque in vivo; however, these important vascular …

Atherosclerosis remains a major cause of morbidity and mortality worldwide, and a thorough
understanding of the underlying pathophysiological mechanisms is crucial for the …

Objectives: This study sought to determine whether low endothelial shear stress (ESS) adds
independent prognostication for future major adverse cardiac events (MACE) in coronary …

Background—Computed tomographic coronary angiography is a noninvasive imaging
modality that permits identification and characterization of coronary plaques. Despite …

In recent years, there has been a significant effort to identify high-risk plaques in vivo prior to
acute events. While number of imaging modalities have been developed to identify …

Coronary plaque rupture is the most common cause of vessel thrombosis and acute
coronary syndrome. The accurate early detection of plaques prone to rupture may allow …

Aims The focal distribution of atherosclerotic plaques suggests that local biomechanical
factors may influence plaque development. Methods and results We studied 40 patients at …

The catastrophic mechanical rupture of an atherosclerotic plaque is the underlying cause of
the majority of cardiovascular events. The infestation of vascular calcification in the plaques …

Computational modelling to calculate the mechanical loading within atherosclerotic plaques
has been shown to be complementary to defining anatomical plaque features in determining …