The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …

Despite the ever-increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the
etiology and pathogenesis remain poorly understood. This is due, in part, to the liver's …

Most spatial transcriptomics technologies are limited by their resolution, with spot sizes
larger than that of a single cell. Although joint analysis with single-cell RNA sequencing can …

The liver carries a remarkable ability to regenerate rapidly after acute zonal damage. Single-
cell approaches are necessary to study this process, given the spatial heterogeneity of liver …

Single-cell proteomics by mass spectrometry is emerging as a powerful and unbiased
method for the characterization of biological heterogeneity. So far, it has been limited to …

Circadian rhythms evolved through adaptation to daily light/dark changes in the
environment; they are believed to be regulated by the core circadian clock interlocking …

Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

The concept of hepatocyte functional zonation is well established, with differences in
metabolism and xenobiotic processing determined by multiple factors including oxygen and …

The liver is an essential organ that is critical for the removal of toxins, the production of
proteins, and the maintenance of metabolic homeostasis. Behind each liver functional unit …

In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based
on their location within the liver lobule. However, it is unclear whether this spatial variation …