A detailed understanding of the human infectious reservoir is essential for improving malaria
transmission-reducing interventions. Here we report a multi-regional assessment of …

Understanding the importance of gametocyte density on human-to-mosquito transmission is
of immediate relevance to malaria control. Previous work (Churcher et al., 2013) indicated a …

Malaria is the major cause of mortality and morbidity in tropical countries. The causative
agent, Plasmodium sp., has a complex life cycle and is armed with various mechanisms …

Background The transmission of malaria to mosquitoes depends on the presence of
gametocytes that circulate in the peripheral blood of infected human hosts. Sensitive …

Background Artemisinins (ART) are the key component of the frontline antimalarial
treatment, but their impact on Plasmodium falciparum sexual conversion rates in natural …

Background Single low-dose primaquine (PQ) reduces Plasmodium falciparum infectivity
before it impacts gametocyte density. Here, we examined the effect of PQ on gametocyte sex …

Background: Malaria elimination strategies require a thorough understanding of parasite
transmission from human to mosquito. A clinical model to induce gametocytes to understand …

Abstract Background The presence of Plasmodium falciparum gametocytes in peripheral
blood is essential for human to mosquito parasite transmission. The detection of …

Background Primaquine (PQ) actively clears mature Plasmodium falciparum gametocytes
but in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals can cause …

Malaria is a serious public health problem worldwide. Globally concerted efforts are
underway to control and eliminate it. Despite recent slowdown, substantial achievements …