Abstract Pyrazolo [1, 5-a] pyrimidine scaffold is one of the privileged hetrocycles in drug
discovery. Its application as a buliding block for developing drug-like candidates has …

A novel series of pyrazolo [1, 5-a] pyrimidines were synthesized and proved by their spectral
and elemental analysis, some elected of the newly synthesized compounds were examined …

In an attempt to find novel α-glucosidase inhibitors, an efficient, straightforward reaction to
synthesize a library of fully substituted 6-amino-pyrazolo [1, 5-a] pyrimidines 3 has been …

A series of novel pyrazolo [1, 5-a] pyrimidine derivatives bearing nitrogen mustard moiety
were designed, synthesized and evaluated for their antiproliferative activities against five …

A novel series of pyrazolo [1, 5-a] pyrimidine ring systems containing phenylsulfonyl moiety
have been synthesized via the reaction of 2-(phenylsulfonyl)-1-(4-(phenylsulfonyl) phenyl) …

A simple and practical four-step protocol for the parallel synthesis of 7-heteroaryl-pyrazolo 1,
5-aa pyrimidine-3-carboxamides was developed. The synthesis starts with transformation of …

The synthesis of 7-substituted pyrazolo [1, 5-a] pyrimidine-3-carboxamides was studied.
First, methyl 7-hydroxypyrazolo [1, 5-a] pyrimidine-3-carboxylate (5) was prepared in three …

A series of novel 7-aminoalkyl substituted pyrazolo [1, 5-a] pyrimidine derivatives were
synthesized and tested for inhibition of cathepsin K. The synthetic methodology comprises …

A novel two-step synthesis of trifluoromethylated 3, 5-disubstituted pyrazolo [1, 5-a]
pyrimidines is reported from 3-aminopyrazoles and ethyl 4, 4, 4-trifluorobut-2-ynoate. The …

Based on the molecular docking simulation and structure of larotrectinib, some larotrectinib
derivatives as antitumor compounds were designed and synthesized. The antitumor …