Antimicrobial host defence peptides: functions and clinical potential
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …
occurring peptides that can combat infections through their direct microbicidal properties …
Cystic fibrosis and Pseudomonas aeruginosa: the host-microbe interface
In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …
The immunology of host defence peptides: beyond antimicrobial activity
Host defence peptides (HDPs) are short, cationic amphipathic peptides with diverse
sequences that are produced by various cells and tissues in all complex life forms. HDPs …
sequences that are produced by various cells and tissues in all complex life forms. HDPs …
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases
B Korkmaz, MS Horwitz, DE Jenne, F Gauthier - Pharmacological reviews, 2010 - ASPET
Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …
Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37
A Krasnodembskaya, Y Song, X Fang, N Gupta… - Stem …, 2010 - academic.oup.com
Recent in vivo studies indicate that mesenchymal stem cells (MSCs) may have beneficial
effects in the treatment of sepsis induced by bacterial infection. Administration of MSCs in …
effects in the treatment of sepsis induced by bacterial infection. Administration of MSCs in …
Strategies employed in the design and optimization of synthetic antimicrobial peptide amphiphiles with enhanced therapeutic potentials
Antimicrobial peptides (AMPs) which predominantly act via membrane active mechanisms
have emerged as an exciting class of antimicrobial agents with tremendous potential to …
have emerged as an exciting class of antimicrobial agents with tremendous potential to …
pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37
MH Abou Alaiwa, LR Reznikov… - Proceedings of the …, 2014 - National Acad Sciences
The pulmonary airways are continuously exposed to bacteria. As a first line of defense
against infection, the airway surface liquid (ASL) contains a complex mixture of antimicrobial …
against infection, the airway surface liquid (ASL) contains a complex mixture of antimicrobial …
Airway epithelium dysfunction in cystic fibrosis and COPD
Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene, whereas chronic
obstructive pulmonary disease (COPD) is mainly caused by environmental factors (mostly …
obstructive pulmonary disease (COPD) is mainly caused by environmental factors (mostly …
Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR
RL Young, KC Malcolm, JE Kret, SM Caceres… - PloS one, 2011 - journals.plos.org
The inability of neutrophils to eradicate Pseudomonas aeruginosa within the cystic fibrosis
(CF) airway eventually results in chronic infection by the bacteria in nearly 80 percent of …
(CF) airway eventually results in chronic infection by the bacteria in nearly 80 percent of …
A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy
K Pohl, E Hayes, J Keenan, M Henry… - Blood, The Journal …, 2014 - ashpublications.org
Studies have endeavored to reconcile whether dysfunction of neutrophils in people with
cystic fibrosis (CF) is a result of the genetic defect or is secondary due to infection and …
cystic fibrosis (CF) is a result of the genetic defect or is secondary due to infection and …