Functional architecture of the retina: development and disease

M Hoon, H Okawa, L Della Santina… - Progress in retinal and eye …, 2014 - Elsevier
Abstract Structure and function are highly correlated in the vertebrate retina, a sensory tissue
that is organized into cell layers with microcircuits working in parallel and together to encode …

GABAA receptors and plasticity of inhibitory neurotransmission in the central nervous system

JM Fritschy, P Panzanelli - European Journal of Neuroscience, 2014 - Wiley Online Library
GABAA receptors (GABAAR s) are ligand‐gated Cl− channels that mediate most of the fast
inhibitory neurotransmission in the central nervous system (CNS). Multiple GABAAR …

[PDF][PDF] SRGAP2 and its human-specific paralog co-regulate the development of excitatory and inhibitory synapses

M Fossati, R Pizzarelli, ER Schmidt, JV Kupferman… - Neuron, 2016 - cell.com
The proper function of neural circuits requires spatially and temporally balanced
development of excitatory and inhibitory synapses. However, the molecular mechanisms …

Emergence of local and global synaptic organization on cortical dendrites

JH Kirchner, J Gjorgjieva - Nature Communications, 2021 - nature.com
Synaptic inputs on cortical dendrites are organized with remarkable subcellular precision at
the micron level. This organization emerges during early postnatal development through …

Adaptation of magnified analysis of the proteome for excitatory synaptic proteins in varied samples and evaluation of cell type-specific distributions

M Delhaye, J LeDue, K Robinson, Q Xu… - Journal of …, 2024 - Soc Neuroscience
Growing evidence suggests a remarkable diversity and complexity in the molecular
composition of synapses, forming the basis for the brain to execute complex behaviors …

[PDF][PDF] Target-specific glycinergic transmission from VGluT3-expressing amacrine cells shapes suppressive contrast responses in the retina

NW Tien, T Kim, D Kerschensteiner - Cell reports, 2016 - cell.com
Neurons that release more than one transmitter exist throughout the CNS. Yet, how these
neurons deploy multiple transmitters and shape the function of specific circuits is not well …

Inhibitory inputs tune the light response properties of dopaminergic amacrine cells in mouse retina

GS Newkirk, M Hoon, RO Wong… - Journal of …, 2013 - journals.physiology.org
Dopamine (DA) is a neuromodulator that in the retina adjusts the circuitry for visual
processing in dim and bright light conditions. It is synthesized and released from retinal …

Dopamine D1 receptor expression is bipolar cell type‐specific in the mouse retina

P Farshi, B Fyk‐Kolodziej, DM Krolewski… - Journal of …, 2016 - Wiley Online Library
In the retina, dopamine is a key molecule for daytime vision. Dopamine is released by retinal
dopaminergic amacrine cells and transmits signaling either by conventional synaptic or by …

Permeabilization-free en bloc immunohistochemistry for correlative microscopy

KA Fulton, KL Briggman - Elife, 2021 - elifesciences.org
A dense reconstruction of neuronal synaptic connectivity typically requires high-resolution
3D electron microscopy (EM) data, but EM data alone lacks functional information about …

Subcellular pathways through VGluT3-expressing mouse amacrine cells provide locally tuned object-motion-selective signals in the retina

K Friedrichsen, JC Hsiang, CI Lin, L McCoy… - Nature …, 2024 - nature.com
VGluT3-expressing mouse retinal amacrine cells (VG3s) respond to small-object motion and
connect to multiple types of bipolar cells (inputs) and retinal ganglion cells (RGCs, outputs) …