The role of adipose tissue and adipokines in sepsis: inflammatory and metabolic considerations, and the obesity paradox

I Karampela, GS Christodoulatos, M Dalamaga - Current obesity reports, 2019 - Springer
Purpose Sepsis has become a global health problem with rising incidence and high
mortality, creating a substantial social and economic burden. Early diagnosis and treatment …

Interplay between the immune and endocrine systems in the lung: implications for TB susceptibility

T Webber, K Ronacher, M Conradie-Smit… - Frontiers in …, 2022 - frontiersin.org
The role of the endocrine system on the immune response, especially in the lung, remains
poorly understood. Hormones play a crucial role in the development, homeostasis …

Inflammatory effects of subacute exposure of roundup in rat liver and adipose tissue

A Pandey, P Dabhade, A Kumarasamy - Dose-response, 2019 - journals.sagepub.com
Roundup is a popular herbicide containing glyphosate as an active ingredient. The
formulation of Roundup is speculated to have critical toxic effects, one among which is …

[HTML][HTML] miR-16 inhibits NLRP3 inflammasome activation by directly targeting TLR4 in acute lung injury

Y Yang, F Yang, X Yu, B Wang, Y Yang, X Zhou… - Biomedicine & …, 2019 - Elsevier
Acute lung injury (ALI) is the leading cause of human death, and it is widely accepted that
the runaway inflammation is an important risk for the development of ALI. In the present …

Necroptosis mediates muscle protein degradation in a cachexia model of weanling pig with lipopolysaccharide challenge

J Guo, X Qin, Y Wang, X Li, X Wang, H Zhu… - International Journal of …, 2023 - mdpi.com
Necroptosis, an actively researched form of programmed cell death closely related to the
inflammatory response, is important in a variety of disorders and diseases. However, the …

Leptin Mediates In Vivo Neutrophil Migration: Involvement of Tumor Necrosis Factor-Alpha and CXCL1

G Souza-Almeida, H D'Avila, PE Almeida… - Frontiers in …, 2018 - frontiersin.org
Leptin directly activates macrophages and lymphocytes, but the role of leptin in neutrophil
activation and migration is still controversial. Here, we investigate the in vivo mechanisms of …

An update on leptin as immunomodulator

J Conde, M Scotece, V Abella, V López… - Expert review of …, 2014 - Taylor & Francis
Until the discovery of leptin 20 years ago, adipose tissue was considered only as a fat
storage organ, involved in the regulation of energy homeostasis. At present, it is well known …

Peripherally administered orexin improves survival of mice with endotoxin shock

Y Ogawa, Y Irukayama-Tomobe, N Murakoshi… - Elife, 2016 - elifesciences.org
Sepsis is a systemic inflammatory response to infection, accounting for the most common
cause of death in intensive care units. Here, we report that peripheral administration of the …

GLP‐1 Analogue Liraglutide Enhances SP‐A Expression in LPS‐Induced Acute Lung Injury through the TTF‐1 Signaling Pathway

T Zhu, C Li, X Zhang, C Ye, S Tang… - Mediators of …, 2018 - Wiley Online Library
The reduction of pulmonary surfactant (PS) is essential for decreased pulmonary
compliance and edema in acute lung injury (ALI). Thyroid transcription factor‐1 (TTF‐1) …

Transcriptome Analysis of Turbot (Scophthalmus maximus) Infected With Aeromonas salmonicida Reveals a Direct Effect on Leptin Synthesis as a Neuroendocrine …

M Librán-Pérez, P Pereiro, A Figueras… - Frontiers in Marine …, 2022 - frontiersin.org
Aeromonas salmonicida subsp. salmonicida is the causative agent of furunculosis, a
disease affecting numerous fish species worldwide. It is a highly pathogenic bacterium for …