Abstract Background Aquaporins (AQPs) are a family of proteins that can act as water
channels. Regulation of AQPs is critical to osmoregulation and the maintenance of body …

Human pluripotent stem cell-derived kidney organoids recapitulate developmental
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …

Saving body water by optimal reabsorption of water filtered by the kidney leading to
excretion of urine with concentrations of solutes largely above that of plasma allowed …

Hypercalcemia can cause renal dysfunction such as nephrogenic diabetes insipidus (NDI),
but the mechanisms underlying hypercalcemia-induced NDI are not well understood. To …

The sodium/proton exchanger isoform 3 (NHE3) is expressed in the intestine and the kidney,
where it facilitates sodium (re) absorption and proton secretion. The importance of NHE3 in …

Zika virus (ZIKV) is a newly emerging flavivirus that broadly exhibits in various bodily tissues
and fluids, especially in the brain, and ZIKV infection often causes microcephaly. Previous …

Hypokalemia (low serum potassium level) is a common electrolyte imbalance that can cause
a defect in urinary concentrating ability, ie, nephrogenic diabetes insipidus (NDI), but the …

The collecting duct (CD) concentrates the urine, thereby maintaining body water volume and
plasma osmolality within a normal range. The endocrine hormone arginine vasopressin acts …

AQP2 function and thus urine concentration is dependent on a variety of cell signalling
mechanisms, posttranslational modification and interplay between AQP2 and its lipid …

Aquaporin-2 (AQP2) is a vasopressin-regulated water channel responsible for regulating
water reabsorption through the apical plasma membrane of the principal cells of renal …