[HTML][HTML] Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …
millions of people worldwide. As the number of AD cases continues to increase in both …
The human side of microglia
AM Smith, M Dragunow - Trends in neurosciences, 2014 - cell.com
Despite increasing evidence of major differences between rodent and human immune and
neurological function, relatively few biomedical studies are performed with human cells. This …
neurological function, relatively few biomedical studies are performed with human cells. This …
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models
Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a
disorder characterized by synapse and memory failure. Irisin is an exercise-induced …
disorder characterized by synapse and memory failure. Irisin is an exercise-induced …
The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non‐human primate model of …
AF Batista, L Forny‐Germano, JR Clarke… - The Journal of …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective
treatment, and this has stimulated an intense pursuit of disease‐modifying therapeutics …
treatment, and this has stimulated an intense pursuit of disease‐modifying therapeutics …
[HTML][HTML] TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys
Alzheimer's disease (AD) and type 2 diabetes appear to share similar pathogenic
mechanisms. dsRNA-dependent protein kinase (PKR) underlies peripheral insulin …
mechanisms. dsRNA-dependent protein kinase (PKR) underlies peripheral insulin …
Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease
Neuronal protein synthesis is essential for long-term memory consolidation, and its
dysregulation is implicated in various neurodegenerative disorders, including Alzheimer's …
dysregulation is implicated in various neurodegenerative disorders, including Alzheimer's …
Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates
L Forny-Germano, NML e Silva, AF Batista… - Journal of …, 2014 - Soc Neuroscience
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a major medical
problem. Here, we have investigated the impact of amyloid-β (Aβ) oligomers, AD-related …
problem. Here, we have investigated the impact of amyloid-β (Aβ) oligomers, AD-related …
[HTML][HTML] d-serine levels in Alzheimer's disease: implications for novel biomarker development
C Madeira, MV Lourenco, C Vargas-Lopes… - Translational …, 2015 - nature.com
Alzheimer's disease (AD) is a severe neurodegenerative disorder still in search of effective
methods of diagnosis. Altered levels of the NMDA receptor co-agonist, d-serine, have been …
methods of diagnosis. Altered levels of the NMDA receptor co-agonist, d-serine, have been …
Astrocyte transforming growth factor beta 1 protects synapses against Aβ oligomers in Alzheimer's disease model
LP Diniz, V Tortelli, I Matias, J Morgado… - Journal of …, 2017 - Soc Neuroscience
Alzheimer9s disease (AD) is characterized by progressive cognitive decline, increasingly
attributed to neuronal dysfunction induced by amyloid-β oligomers (AβOs). Although the …
attributed to neuronal dysfunction induced by amyloid-β oligomers (AβOs). Although the …
[HTML][HTML] Extracellular vesicles derived from human Wharton's jelly mesenchymal stem cells protect hippocampal neurons from oxidative stress and synapse damage …
V Bodart-Santos, LRP de Carvalho… - Stem cell research & …, 2019 - Springer
Abstract Background Mesenchymal stem cells (MSCs) have been explored as promising
tools for treatment of several neurological and neurodegenerative diseases. MSCs release …
tools for treatment of several neurological and neurodegenerative diseases. MSCs release …