Brain and peripheral atypical inflammatory mediators potentiate neuroinflammation and neurodegeneration

D Kempuraj, R Thangavel, GP Selvakumar… - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …

Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases

S Gangemi, E Gofita, C Costa… - International …, 2016 - spandidos-publications.com
Pesticides can exert numerous effects on human health as a consequence of both
environmental and occupational exposures. The available knowledge base suggests that …

Triggering of inflammasome by aggregated α–synuclein, an inflammatory response in synucleinopathies

G Codolo, N Plotegher, T Pozzobon, M Brucale… - PloS one, 2013 - journals.plos.org
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. It is
characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta of …

Anti-inflammatory activity of ursolic acid in MPTP-induced parkinsonian mouse model

SN Rai, W Zahra, SS Singh, H Birla, C Keswani… - Neurotoxicity …, 2019 - Springer
Neuroinflammation plays an important role in the progression of Parkinson's disease (PD)
and hence may represent a target for treatment. The drugs used currently for PD only …

Immunomodulatory effects of dopamine in inflammatory diseases

Y Feng, Y Lu - Frontiers in immunology, 2021 - frontiersin.org
Dopamine (DA) receptor, a significant G protein-coupled receptor, is classified into two
families: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptor families, with further …

β-Caryophyllene, a phytocannabinoid attenuates oxidative stress, neuroinflammation, glial activation, and salvages dopaminergic neurons in a rat model of Parkinson …

S Ojha, H Javed, S Azimullah, ME Haque - Molecular and cellular …, 2016 - Springer
Parkinson disease (PD) is a neurodegenerative disease characterized by progressive
dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) area. The …

New insights into the ameliorative effects of ferulic acid in pathophysiological conditions

S Ghosh, P Basak, S Dutta, S Chowdhury… - Food and Chemical …, 2017 - Elsevier
Ferulic acid, a natural phytochemical has gained importance as a potential therapeutic
agent by virtue of its easy commercial availability, low cost and minimal side-effects. It is a …

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson's disease

S Ojha, H Javed, S Azimullah… - Drug design …, 2015 - Taylor & Francis
Parkinson's disease (PD) is a chronic, progressive, and the second most common form of
neurodegenerative disorders. In order to explore novel agents for the treatment of PD, in the …

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

SJ Chinta, CA Lieu, M DeMaria… - Journal of internal …, 2013 - Wiley Online Library
Exposure to environmental toxins is associated with a variety of age‐related diseases
including cancer and neurodegeneration. For example, in Parkinson's disease (PD), chronic …

Inflammation in Parkinson's disease

KU Tufekci, R Meuwissen, S Genc, K Genc - Advances in protein chemistry …, 2012 - Elsevier
Parkinson's disease (PD) is a common neurodegenerative disease that is characterized by
the degeneration of dopaminergic neurons in the substantia nigra pars compacta …