Survival improves when cancer is detected early. However,~ 50% of cancers are at an
advanced stage when diagnosed. Early detection of cancer or precancerous change allows …

Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Oncogene amplification on extrachromosomal DNA (ecDNA) drives the evolution of tumours
and their resistance to treatment, and is associated with poor outcomes for patients with …

The origin of human metaplastic states and their propensity for cancer is poorly understood.
Barrett's esophagus is a common metaplastic condition that increases the risk for …

Deep learning methods have been shown to achieve excellent performance on diagnostic
tasks, but how to optimally combine them with expert knowledge and existing clinical …

Intestinal metaplasia in the esophagus (Barrett's esophagus IM, or BE-IM) and stomach
(GIM) are considered precursors for esophageal and gastric adenocarcinoma, respectively …

Background Endoscopic surveillance is recommended for patients with Barrett's
oesophagus because, although the progression risk is low, endoscopic intervention is highly …

The progression of precancerous lesions to malignancy is often accompanied by increasing
complexity of chromosomal alterations but how these alterations arise is poorly understood …

Barrett oesophagus, in which a metaplastic columnar mucosa that can predispose
individuals to cancer development lines a portion of the distal oesophagus, is the only …

Opinion statement Considerable advances in the investigation and management of
oesophagogastric cancer have occurred over the last few decades. While the historically …