Cannabidiol: State of the art and new challenges for therapeutic applications

S Pisanti, AM Malfitano, E Ciaglia, A Lamberti… - Pharmacology & …, 2017 - Elsevier
Over the past years, several lines of evidence support a therapeutic potential of Cannabis
derivatives and in particular phytocannabinoids. Δ 9-THC and cannabidiol (CBD) are the …

Immune responses regulated by cannabidiol

JM Nichols, BLF Kaplan - Cannabis and cannabinoid research, 2020 - liebertpub.com
Introduction: Cannabidiol (CBD) as Epidiolex®(GW Pharmaceuticals) was recently
approved by the US Food and Drug Administration (FDA) to treat rare forms of epilepsy in …

From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology

A Ligresti, L De Petrocellis… - Physiological …, 2016 - journals.physiology.org
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

Cannabidiol (CBD) and its analogs: a review of their effects on inflammation

S Burstein - Bioorganic & medicinal chemistry, 2015 - Elsevier
First isolated from Cannabis in 1940 by Roger Adams, the structure of CBD was not
completely elucidated until 1963. Subsequent studies resulted in the pronouncement that …

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain

CD Verrico, S Wesson, V Konduri, CJ Hofferek… - Pain, 2020 - journals.lww.com
1. Background Arthritis is a leading cause of pain, disfigurement, and disability in the United
States where nearly one-quarter of all adults have received an affirmative diagnosis. 2 …

[HTML][HTML] Antioxidant therapy for treatment of inflammatory bowel disease: does it work?

FA Moura, KQ de Andrade, JCF Dos Santos… - Redox biology, 2015 - Elsevier
Oxidative stress (OS) is considered as one of the etiologic factors involved in several signals
and symptoms of inflammatory bowel diseases (IBD) that include diarrhea, toxic megacolon …

The Effects of Cannabinoids on Pro- and Anti-Inflammatory Cytokines: A Systematic Review of In Vivo Studies

FR Henshaw, LS Dewsbury, CK Lim… - Cannabis and …, 2021 - liebertpub.com
Introduction: Some cannabinoids have been identified as anti-inflammatory agents;
however, their potential therapeutic or prophylactic applications remain controversial. The …

Comprehensive review of medicinal marijuana, cannabinoids, and therapeutic implications in medicine and headache: what a long strange trip it's been…

EP Baron - Headache: The Journal of Head and Face Pain, 2015 - Wiley Online Library
Background The use of cannabis, or marijuana, for medicinal purposes is deeply rooted
though history, dating back to ancient times. It once held a prominent position in the history …

Cannabis induces a clinical response in patients with Crohn's disease: a prospective placebo-controlled study

T Naftali, LBL Schleider, I Dotan, EP Lansky… - Clinical …, 2013 - Elsevier
Background & Aims The marijuana plant Cannabis sativa has been reported to produce
beneficial effects for patients with inflammatory bowel diseases, but this has not been …

[HTML][HTML] Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals?

V Martínez, A Iriondo De-Hond, F Borrelli… - International Journal of …, 2020 - mdpi.com
Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used
for different purposes, like the production of fibers, the production of oil from the seeds, and …