Type 2 diabetes mellitus (T2DM) is a very complex and multifactorial metabolic disease
characterized by insulin resistance and β cell failure leading to elevated blood glucose …

Diabetes mellitus is a multifactorial disease, classically influenced by genetic determinants
of individual susceptibility and by environmental accelerating factors, such as lifestyle. It is …

Hepatic insulin resistance is an important underlying cause of the metabolic syndrome that
manifests itself in diseases such as diabetes type II, atherosclerosis or non-alcoholic fatty …

The formation of advanced glycation end products (AGEs) is a key pathophysiological event
with links to a range of important human diseases. It is now clear that AGEs may act as …

Insulin is a key hormone regulating the control of metabolism and the maintenance of
normoglycaemia and normolipidaemia. Insulin acts by binding to its cell surface receptor …

Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …

Retinopathy is one of the commonest microvascular complications of diabetes and is still the
prevailing cause of registerable blindness in the working population of developed countries …

We have studied the effect of the administration of two doses of melatonin (melatonin 100
and melatonin 200 μg/kg bw) on diabetes and oxidative stress experimentally induced by …

Diabetic complications are major cause of morbidity and mortality in patients with diabetes.
While the precise pathogenic mechanism (s) underlying conditions such as diabetic …

The first diabetic patient was treated with insulin in January 1922, revolutionizing the
treatment of diabetes mellitus. The discovery and purification of insulin was the result of the …