Valve disease and particularly calcific aortic valve disease (CAVD) and diabetes (DM) are
progressive diseases constituting a global health burden for all aging societies (Progress in …

Hepatic cancer is one of the most widespread maladies worldwide that requires urgent
therapies and thus reliable means for testing anti-cancer drugs. The switch from two …

Calcific aortic valve disease (CAVD)—the most common valvular heart disease—is
accelerated in diabetes and has no pharmacotherapy. Although it is known that early CAVD …

As the most prevalent valvular heart disease, calcific aortic valve disease (CAVD) is a major
health problem with risk of severe morbidity and mortality in the absence of effective medical …

Calcific aortic valve disease (CAVD), a degenerative disease characterized by inflammation,
fibrosis and calcification, is accelerated in diabetes. Hyperglycemia contributes to this …

ABSTRACT Aims/Introduction Linagliptin is a selective dipeptidyl peptidase (DPP)‐4
inhibitor capable of successfully regulating blood glucose levels. The cardiovascular …

Background: Valvular endothelial cells (VEC) have key roles in maintaining valvular integrity
and homeostasis, and dysfunctional VEC are the initiators and major contributors to aortic …

Background Mounting evidence indicates that rapid progression of aortic stenosis (AS) is
significantly associated with poor prognosis. Whether diabetes accelerates the progression …

Diabetes reduces the number and induces dysfunction in circulating endothelial progenitor
cells (EPCs) by mechanisms that are still uncovered. This study aims to evaluate the …

Endothelial to mesenchymal transition (EndMT) of valvular endothelial cells (VEC) is a key
process in the development and progression of calcific aortic valve disease (CAVD). High …