Almost half a century after the first reports describing the limited replicative potential of
primary cells in culture, there is now overwhelming evidence for the existence of “cellular …

The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However,
this is a disguise that conceals a highly active metabolic cell state with diverse functionality …

Approximately 33% of melanomas are derived directly from benign, melanocytic nevi.
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …

Mammalian wound healing involves the rapid synthesis and deposition of extracellular
matrix (ECM) to maintain tissue integrity during repair. This process must be tightly …

In late 1990s, it was shown that activated oncogenes are able to induce senescence. Since
then large leaps in understanding this phenomenon have been achieved. There is …

Senescence is involved in various pathophysiological conditions. Besides loss of
retinoblastoma and p53 pathways, little is known about other pathways involved in …

The insulin/insulin-like growth factors (IGFs) have crucial tasks in the growth, differentiation,
and proliferation of healthy and pernicious cells. They are involved in coordinated …

Advances in deep genomic sequencing have identified a spectrum of cancer-specific
passenger and driver aberrations. Clones with driver anomalies are believed to be positively …

Although senescence was originally described as an in vitro acquired cellular characteristic,
it was recently recognized that senescence is physiologically and pathologically involved in …

Cellular senescence is now recognized as one of the nine hallmarks of ageing. Recent data
show the involvement of senescent cells in tissue ageing and some age-related diseases …