Zinc is one of the most abundant metal ions in the central nervous system (CNS), where it
plays a crucial role in both physiological and pathological brain functions. Zinc promotes …

The divalent cation zinc is an integral requirement for optimal cellular processes, whereby it
contributes to the function of over 300 enzymes, regulates intracellular signal transduction …

Promoting successful cognitive aging is a topic of major importance to individuals and the
field of public health. This review presents a coherent framework not only for evaluating …

Mitochondrial dysfunction is observed in Alzheimer's disease (AD) brain, and the amyloid-β
(Aβ) peptide is known to induce mitochondrial dysfunction. The relative degree of …

Zinc is necessary for not only brain development but also brain function. Zinc homeostasis in
the brain is tightly regulated by the brain barrier system and is not easily disrupted by dietary …

Metal dyshomeostasis in the brain (BMD) has often been proposed as a possible cause for
several neurodegenerative disorders (NDs). Nevertheless, the precise nature of the …

Mutations in the metalloenzyme copper-zinc superoxide dismutase (SOD1) cause one form
of familial amyotrophic lateral sclerosis (ALS), and metals are suspected to play a pivotal …

Mammalian metallothioneins (MTs) are low molecular weight (6–7 kDa) cysteine-rich
proteins that are specifically induced by metal nanoparticles (NPs). MT induction in cell …

Aging is an inevitable biological process, associated with gradual and spontaneous
biochemical and physiological changes, and increased susceptibility to diseases. Chronic …

Aging is characterized by a progressive decline of cognitive performance, which has been
partially attributed to structural and functional alterations of hippocampus. Importantly, aging …