Immunosenescence and human vaccine immune responses

SN Crooke, IG Ovsyannikova, GA Poland… - Immunity & …, 2019 - Springer
The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Biology of infection and disease pathogenesis to guide RSV vaccine development

S Boyoglu-Barnum, T Chirkova… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease
in young children and a substantial contributor to respiratory tract disease throughout life …

Longitudinal humoral analysis in RSV-infected infants identifies pre-existing RSV strain-specific G and evolving cross-reactive F antibodies

N Nziza, W Jung, M Mendu, T Chen, B Julg, B Graham… - Immunity, 2024 - cell.com
Respiratory syncytial virus (RSV) is among the most common causes of lower respiratory
tract infection (LRTI) and hospitalization in infants. However, the mechanisms of immune …

Host responses to respiratory syncytial virus infection

A Agac, SM Kolbe, M Ludlow, ADME Osterhaus… - Viruses, 2023 - mdpi.com
Respiratory syncytial virus (RSV) infections are a constant public health problem, especially
in infants and older adults. Virtually all children will have been infected with RSV by the age …

Broad antibody and cellular immune response from a phase 2 clinical trial with a novel multivalent poxvirus-based respiratory syncytial virus vaccine

E Jordan, SJ Lawrence, TPH Meyer… - The Journal of …, 2021 - academic.oup.com
Background Respiratory syncytial virus (RSV) is a major cause of severe respiratory disease
in young children and the elderly. Protective immunity is not generated after repeated …

Considerations for a respiratory syncytial virus vaccine targeting an elderly population

LM Stephens, SM Varga - Vaccines, 2021 - mdpi.com
Respiratory syncytial virus (RSV) is most commonly associated with acute lower respiratory
tract infections in infants and children. However, RSV also causes a high disease burden in …

Immunity cell responses to RSV and the role of antiviral inhibitors: a systematic review

G Churiso, G Husen, D Bulbula… - Infection and drug …, 2022 - Taylor & Francis
Antigen-presenting cells recognize respiratory syncytial virus antigens, and produce
cytokines and chemokines that act on immune cells. Dendritic cells play the main role in …

Immunopathogenesis of Nipah virus infection and associated immune responses

B Brown, T Gravier, I Fricke, SA Al-Sheboul, TN Carp… - Immuno, 2023 - mdpi.com
Pandemics in the last two centuries have been initiated by causal pathogens that include
Severe Acute Coronavirus 2 (SARS-CoV-2) and Influenza (eg, the H1N1 pandemic of 2009) …

Adenovectors encoding RSV-F protein induce durable and mucosal immunity in macaques after two intramuscular administrations

NC Salisch, A Izquierdo Gil, DN Czapska-Casey… - npj Vaccines, 2019 - nature.com
Abstract Respiratory Syncytial Virus (RSV) can cause severe respiratory disease, yet a
licensed vaccine is not available. We determined the immunogenicity of two homologous …

[HTML][HTML] Environmental cadmium enhances lung injury by respiratory syncytial virus infection

X Hu, K Kim, Y Lee, J Fernandes, MR Smith… - The American journal of …, 2019 - Elsevier
Cadmium (Cd) is a naturally occurring environmental toxicant that disrupts mitochondrial
function at occupational exposure levels. The impacts of Cd exposure at low levels through …