Preeclampsia is a persistent hypertensive gestational disease characterized by high blood
pressure and proteinuria, which presents from the second trimester of pregnancy. At the …

Metformin is everywhere. Originally introduced in clinical practice as an antidiabetic agent,
its role as a therapeutic agent is expanding to include treatment of prediabetes mellitus …

Pregnancy, mostly because of the mitochondria-rich placenta, is a condition that favors
oxidative stress. Transitional metals, especially iron, which is particularly abundant in the …

Proper placental development and function are central to the health of both the mother and
the fetus during pregnancy. A critical component of healthy placental function is the proper …

The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the
detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite …

Objective: Accumulating evidence suggests that the balance between vascular endothelial
growth factor (VEGF), placental growth factor (PlGF), and their receptors is important for …

Oxidative stress may be defined as an imbalance between pro-oxidant and antioxidant
forces resulting in an overall pro-oxidant insult. Pregnancy is a physiological state …

Oxidative stress has been clearly linked to type 2 diabetes mellitus, however, limited data
are available on the involvement of oxidative stress in gestational diabetes mellitus (GDM), a …

Recent evidence suggests that oxidative stress is involved in the pathophysiology of
preeclampsia. Using immunohistochemistry and Western blotting, we investigated the …

OBJECTIVE: To determine whether maternal plasma concentrations of placental growth
factor (PlGF), soluble endoglin (sEng), and soluble vascular endothelial growth factor …