Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …

Cellular stress, induced by external or internal cues, activates several well-orchestrated
processes aimed at either restoring cellular homeostasis or committing to cell death. Those …

Mitochondria are primarily responsible for providing the contracting cardiac myocyte with a
continuous supply of ATP. However, mitochondria can rapidly change into death-promoting …

Missense mutations in PTEN-induced kinase 1 (PINK1) cause autosomal-recessive
inherited Parkinson's disease (PD). We have exploited our recent discovery that …

Mitochondria have emerged as key actors of innate and adaptive immunity. Mitophagy has a
pivotal role in cell homeostasis, but its contribution to macrophage functions and host …

Recent advances in mitochondrial biology have revealed the high diversity and complexity
of proteolytic enzymes that regulate mitochondrial function. We have classified mitochondrial …

Impairment of PINK 1/parkin‐mediated mitophagy is currently proposed to be the molecular
basis of mitochondrial abnormality in Parkinson's disease (PD). We here demonstrate that …

Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and
mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the …

Parkinson's disease is the most common neurodegenerative movement disorder. Mutations
in PINK1 and PARKIN are the most frequent causes of recessive Parkinson's disease …