Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …

Psychiatric patients have a greater risk of premature mortality, predominantly due to
cardiovascular diseases (CVDs). Convincing evidence shows that psychiatric conditions are …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

We examined whether inflammation is uniformly associated with all depressive and anxiety
symptoms, and whether these associations are potentially causal. Data was from 147,478 …

Depression is a polygenic trait that causes extensive periods of disability. Previous genetic
studies have identified common risk variants which have progressively increased in number …

Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …

Depression's burden of disease goes beyond functioning and quality of life and extends to
somatic health. Results from longitudinal cohort studies converge in illustrating that major …

The gut microbiome is thought to play a role in depressive disorders, which makes it an
attractive target for interventions. Both the microbiome and depressive symptom levels vary …

Epidemiological evidence indicates the presence of dysregulated homeostatic biological
pathways in depressed patients, such as increased inflammation and disrupted energy …

Importance Observational studies highlight associations of C-reactive protein (CRP), a
general marker of inflammation, and interleukin 6 (IL-6), a cytokine-stimulating CRP …