One of the features of primate immunodeficiency viruses (HIVs and SIVs) that distinguishes
them from other retroviruses is the array of" accessory" proteins they encode. Here, we …

In the last decade, the ubiquitin–proteasome system has emerged as a valid target for the
development of novel therapeutics. E3 ubiquitin ligases are particularly attractive targets …

The HIV auxiliary protein Vpr potently blocks the cell cycle at the G2/M transition. Here, we
show that G2/M arrest results from untimely activation of the structure-specific endonuclease …

To replicate their genomes in cells and generate new progeny, viruses typically require
factors provided by the cells that they have infected. Subversion of the cellular machinery …

The versatility of ubiquitin in regulating protein function and cell behaviour through post-
translational protein modification makes it a particularly attractive target for viruses. Here we …

Myeloid cells play numerous roles in HIV-1 pathogenesis serving as a vehicle for viral
spread and as a viral reservoir. Yet, cells of this lineage generally resist HIV-1 infection …

The HIV protein, Vpr, is a multifunctional accessory protein critical for efficient viral infection
of target CD4+ T cells and macrophages. Vpr is incorporated into virions and functions to …

During the initial stages of carcinogenesis, transformation events occur in a single cell within
an epithelial monolayer. However, it remains unknown what happens at the interface …

RNA viruses are a genetically diverse group of pathogens that are responsible for some of
the most prevalent and lethal human diseases. Numerous viruses introduce DNA damage …

Reactive oxygen species regulate redox-signaling processes, but in excess they can cause
cell damage, hence underlying the aetiology of several neurological diseases. Through its …