Snake venom toxins: Potential anticancer therapeutics

BC Offor, LA Piater - Journal of Applied Toxicology, 2024 - Wiley Online Library
Snake venom contains a cocktail of compounds dominated by proteins and peptides, which
make up the toxin. The toxin components of snake venom attack several targets in the …

Bibliometric analysis of literature in snake venom-related research worldwide (1933–2022)

F Sofyantoro, DS Yudha, K Lischer, TR Nuringtyas… - Animals, 2022 - mdpi.com
Simple Summary Around the world, snake envenomation poses a serious health risk.
Proteins with pharmacological effects are present in snake venom. Recent studies elaborate …

Oxidative stress induced by Pollonein-LAAO, a new L-amino acid oxidase from Bothrops moojeni venom, prompts prostate tumor spheroid cell death and impairs the …

L Polloni, TR Costa, LP Morais, BC Borges… - Cellular …, 2023 - Elsevier
Cancer cells produce abnormal levels of reactive oxygen species (ROS) that contribute to
promote their malignant phenotype. In this framework, we hypothesized that the change in …

Potential of Orlistat to induce apoptotic and antiangiogenic effects as well as inhibition of fatty acid synthesis in breast cancer cells

JV Jovankić, DD Nikodijević, MG Milutinović… - European Journal of …, 2023 - Elsevier
Breast cancer as most often women's cancer is the second cause of mortality worldwide.
Research interest increased in testing non-standard drugs to suppress breast cancer …

Emerging anticancer potential and mechanisms of snake venom toxins: A review

X Guo, Y Fu, J Peng, Y Fu, S Dong, RB Ding… - International Journal of …, 2024 - Elsevier
Animal-derived venom, like snake venom, has been proven to be valuable natural resources
for the drug development. Previously, snake venom was mainly investigated in its …

Structural Determinants of the Specific Activities of an L-Amino Acid Oxidase from Pseudoalteromonas luteoviolacea CPMOR-1 with Broad Substrate Specificity

KJ Mamounis, ML Caldas Nogueira… - Molecules, 2022 - mdpi.com
The Pseudoalteromonas luteoviolacea strain CPMOR-1 expresses a flavin adenine
dinucleotide (FAD)-dependent L-amino acid oxidase (LAAO) with broad substrate specificity …

Resistance to 5-fluorouracil: The molecular mechanisms of development in colon cancer cells

N Radenković, D Nikodijević, J Jovankić… - European journal of …, 2024 - Elsevier
Colon cancer is a significant health problem worldwide as it is one of the most common and
deadliest cancers. The standard approach for the treatment of colon cancer is 5-fluorouracil …

Substituted kynurenic acid derivatives as fluorophore-based probes for d-and l-amino acid oxidase assays and their in vitro application in eels

T Sakamoto, M Onozato, H Sugasawa, T Fukushima - Analyst, 2023 - pubs.rsc.org
High levels of D-amino acid oxidase (DAO) are associated with neurological and psychiatric
disorders, while L-amino acid oxidase (LAO) exhibits antimicrobial and antitumor properties …

Potential of Melittin to induce apoptosis and overcome multidrug resistance in human colon cancer cell line

DD Nikodijević, JV Jovankić, NM Radenković… - Toxin …, 2024 - Taylor & Francis
In this study, the anticancer effect of Melittin was demonstrated through its antiproliferative
and proapoptotic effects on HT-29 cells, as well as its ability to reverse multidrug resistance …

The impact of medicinal plant Ocimum minimum L. on fatty acid synthesis process in breast cancer cells

JV Jovankić, DM Cvetković, MG Milutinović… - Biologia, 2022 - Springer
Breast cancer is the most diagnosed invasive cancer and the second leading cause of
cancer in women. Standard medicinal protocol for treatment of this disease implies surgery …