Glutathione synthesis

SC Lu - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: Glutathione (GSH) is present in all mammalian tissues as the most
abundant non-protein thiol that defends against oxidative stress. GSH is also a key …

Ferroptosis: bug or feature?

SJ Dixon - Immunological reviews, 2017 - Wiley Online Library
Ferroptosis is an iron‐dependent, oxidative form of non‐apoptotic cell death. This form of
cell death does not share morphological, biochemical, or genetic similarities with classic …

Glutathione: overview of its protective roles, measurement, and biosynthesis

HJ Forman, H Zhang, A Rinna - Molecular aspects of medicine, 2009 - Elsevier
This review is the introduction to a special issue concerning, glutathione (GSH), the most
abundant low molecular weight thiol compound synthesized in cells. GSH plays critical roles …

Biogreen synthesis of carbon dots for biotechnology and nanomedicine applications

KK Chan, SHK Yap, KT Yong - Nano-micro letters, 2018 - Springer
Over the past decade, carbon dots have ignited a burst of interest in many different fields,
including nanomedicine, solar energy, optoelectronics, energy storage, and sensing …

Regulation of glutathione synthesis

SC Lu - Molecular aspects of medicine, 2009 - Elsevier
Glutathione (GSH) is a ubiquitous intracellular peptide with diverse functions that include
detoxification, antioxidant defense, maintenance of thiol status, and modulation of cell …

Cellular glutathione and thiols metabolism

DA Dickinson, HJ Forman - Biochemical pharmacology, 2002 - Elsevier
Low molecular weight thiol-containing compounds have an essential role in many
biochemical and pharmacological reactions due to the ease with each they are oxidized …

Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective

W Lewis, BJ Day, WC Copeland - Nature reviews Drug discovery, 2003 - nature.com
Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse
transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years …

Glutathione in defense and signaling: lessons from a small thiol

DA Dickinson, HJ Forman - Annals of the New York Academy of …, 2002 - Wiley Online Library
The mechanisms of thiol metabolism and chemistry have particular relevance to both
cellular defenses against toxicant exposure and to redox signaling. Here, we will focus on …

N‐acetylcysteine replenishes glutathione in HIV infection

SC De Rosa, MD Zaretsky, JG Dubs… - European journal of …, 2000 - Wiley Online Library
Background Glutathione (GSH) deficiency is common in HIV‐infected individuals and is
associated with impaired T cell function and impaired survival. N‐acetylcysteine (NAC) is …

Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 Tat protein under the regulation of the astrocyte-specific glial fibrillary acidic …

BO Kim, Y Liu, Y Ruan, ZC Xu, L Schantz… - The American journal of …, 2003 - Elsevier
The human immunodeficiency virus type 1 (HIV-1) Tat protein is a key pathogenic factor in a
variety of acquired immune deficiency syndrome (AIDS)-associated disorders. A number of …