Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous
system. Over the past decade, our understanding of this disease has advanced …

Antibodies are important therapeutic agents for cancer. Recently, it has become clear that
antibodies possess several clinically relevant mechanisms of action. Many clinically useful …

Purpose: Vα24-invariant natural killer T cells (NKT) are attractive carriers for chimeric
antigen receptors (CAR) due to their inherent antitumor properties and preferential …

Abstract Treatment of cancer is a double-edged sword: it should be as aggressive as
possible to completely destroy the tumour, but it is precisely this aggressiveness which often …

Purpose Anti-GD2 monoclonal antibody (MoAb) combined with granulocyte-macrophage
colony-stimulating factor (GM-CSF) has shown efficacy against neuroblastoma (NB) …

Tumor‐targeting monoclonal antibodies are available for a number of cancer cell types
(over) expressing the corresponding tumor antigens. Such antibodies can limit tumor …

Ganglioside GD2 is highly expressed on neuroectoderm-derived tumors and sarcomas,
including neuroblastoma, retinoblastoma, melanoma, small cell lung cancer, brain tumors …

Neuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system which accounts
for 8% of childhood cancers. Most NBs express high levels of the disialoganglioside GD2 …

Современные фундаментальные исследования убедительно свидетельствуют о том,
что нейтрофильные гранулоциты (НГ) являются ключевыми эффекторными и …

Murine IgG3 anti-GD2 antibody m3F8 has shown anti-neuroblastoma activity in Phase I/II
studies, where antibody-dependent cell-mediated cytotoxicity (ADCC) played a key role …