The understanding of vertebrate development has advanced considerably in recent years,
primarily due to the study of a few model organisms. The zebrafish, the newest of these …

The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and
cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the …

We describe a series of stages for development of the embryo of the zebrafish, Danio
(Brachydanio) rerio. We define seven broad periods of embryogenesis—the zygote …

The sequencing of the zebrafish genome should be completed by the end of 2002. Direct
assignment of function on the basis of this information would be facilitated by the …

The maturation of single-cell transcriptomic technologies has facilitated the generation of
comprehensive cellular atlases from whole embryos,,–. A majority of these data, however …

The zebrafish has become one of the most important model organisms to study biologial
processes in vivo. As a vertebrate that has many of the strengths of invertebrate model …

We describe the use of zinc-finger nucleases (ZFNs) for somatic and germline disruption of
genes in zebrafish (Danio rerio), in which targeted mutagenesis was previously intractable …

Holoprosencephaly (HPE) is a common developmental defect of the forebrain and
frequently the midface in humans, with both genetic and environmental causes. HPE has a …

Holt-Oram syndrome is a developmental disorder affecting the heart and upper limb, the
gene for which was mapped to chromosome 12 two years ago. We have now identified a …

The signals directing primordial germ cell (PGC) migration in vertebrates are largely
unknown. We demonstrate that sdf-1 mRNA is expressed in locations where PGCs are …