[HTML][HTML] Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

P Lundquist, P Artursson - Advanced drug delivery reviews, 2016 - Elsevier
In this contribution, we review the molecular and physiological barriers to oral delivery of
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …

The challenges of oral drug delivery via nanocarriers

J Reinholz, K Landfester, V Mailänder - Drug delivery, 2018 - Taylor & Francis
The oral application of pharmaceuticals is unarguably the most convenient method of
application. Especially for protein-or peptide-based drugs, however, the effectiveness is …

Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery

EM Pridgen, F Alexis, TT Kuo… - Science translational …, 2013 - science.org
Nanoparticles are poised to have a tremendous impact on the treatment of many diseases,
but their broad application is limited because currently they can only be administered by …

The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy

JT Sockolosky, FC Szoka - Advanced drug delivery reviews, 2015 - Elsevier
Immunoglobulin G (IgG)-based drugs are arguably the most successful class of protein
therapeutics due in part to their remarkably long blood circulation. This arises from IgG …

In vitro and in vivo models for the study of oral delivery of nanoparticles

JM Gamboa, KW Leong - Advanced drug delivery reviews, 2013 - Elsevier
Oral delivery is an attractive route to deliver therapeutics via nanoparticles due to its ease of
administration and patient compliance. This review discusses laboratory techniques for …

Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures

K Murugan, YE Choonara, P Kumar… - International journal …, 2015 - Taylor & Francis
Cellular internalization and trans-barrier transport of nanoparticles can be manipulated on
the basis of the physicochemical and mechanical characteristics of nanoparticles. Research …

PEGylated nanomedicines: recent progress and remaining concerns

D Vllasaliu, R Fowler, S Stolnik - Expert opinion on drug delivery, 2014 - Taylor & Francis
Introduction: Recent biopharma deals related to nanocarrier drug delivery technologies
highlight the emergence of nanomedicine. This is perhaps an expected culmination of many …

A comprehensive review of the neonatal Fc receptor and its application in drug delivery

JP Martins, PJ Kennedy, HA Santos, C Barrias… - Pharmacology & …, 2016 - Elsevier
Advances in the understanding of neonatal Fc receptor (FcRn) biology and function have
demonstrated that this receptor, primarily identified for the transfer of passive immunity from …

Oral drug delivery of nanomedicine

D Sahoo, R Bandaru, SK Samal, R Naik… - Theory and applications …, 2021 - Elsevier
Oral drug delivery is the most preferred administration route due to noninvasive, high patient
compliance, convenient to handle, and does not require any specific sterile conditions …

Fc-modified exenatide-loaded nanoparticles for oral delivery to improve hypoglycemic effects in mice

Y Shi, X Sun, L Zhang, K Sun, K Li, Y Li, Q Zhang - Scientific reports, 2018 - nature.com
To improve the oral efficiency of exenatide, we prepared polyethylene glycol-poly (lactic-co-
glycolic acid)(PEG-PLGA) NPs modified with Fc (NPs-Fc) for exenatide oral delivery …