[HTML][HTML] Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
P Lundquist, P Artursson - Advanced drug delivery reviews, 2016 - Elsevier
In this contribution, we review the molecular and physiological barriers to oral delivery of
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …
peptides and nanoparticles. We discuss the opportunities and predictivity of various in vitro …
The challenges of oral drug delivery via nanocarriers
J Reinholz, K Landfester, V Mailänder - Drug delivery, 2018 - Taylor & Francis
The oral application of pharmaceuticals is unarguably the most convenient method of
application. Especially for protein-or peptide-based drugs, however, the effectiveness is …
application. Especially for protein-or peptide-based drugs, however, the effectiveness is …
Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery
EM Pridgen, F Alexis, TT Kuo… - Science translational …, 2013 - science.org
Nanoparticles are poised to have a tremendous impact on the treatment of many diseases,
but their broad application is limited because currently they can only be administered by …
but their broad application is limited because currently they can only be administered by …
The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy
JT Sockolosky, FC Szoka - Advanced drug delivery reviews, 2015 - Elsevier
Immunoglobulin G (IgG)-based drugs are arguably the most successful class of protein
therapeutics due in part to their remarkably long blood circulation. This arises from IgG …
therapeutics due in part to their remarkably long blood circulation. This arises from IgG …
In vitro and in vivo models for the study of oral delivery of nanoparticles
Oral delivery is an attractive route to deliver therapeutics via nanoparticles due to its ease of
administration and patient compliance. This review discusses laboratory techniques for …
administration and patient compliance. This review discusses laboratory techniques for …
Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures
Cellular internalization and trans-barrier transport of nanoparticles can be manipulated on
the basis of the physicochemical and mechanical characteristics of nanoparticles. Research …
the basis of the physicochemical and mechanical characteristics of nanoparticles. Research …
PEGylated nanomedicines: recent progress and remaining concerns
D Vllasaliu, R Fowler, S Stolnik - Expert opinion on drug delivery, 2014 - Taylor & Francis
Introduction: Recent biopharma deals related to nanocarrier drug delivery technologies
highlight the emergence of nanomedicine. This is perhaps an expected culmination of many …
highlight the emergence of nanomedicine. This is perhaps an expected culmination of many …
A comprehensive review of the neonatal Fc receptor and its application in drug delivery
Advances in the understanding of neonatal Fc receptor (FcRn) biology and function have
demonstrated that this receptor, primarily identified for the transfer of passive immunity from …
demonstrated that this receptor, primarily identified for the transfer of passive immunity from …
Oral drug delivery of nanomedicine
Oral drug delivery is the most preferred administration route due to noninvasive, high patient
compliance, convenient to handle, and does not require any specific sterile conditions …
compliance, convenient to handle, and does not require any specific sterile conditions …
Fc-modified exenatide-loaded nanoparticles for oral delivery to improve hypoglycemic effects in mice
Y Shi, X Sun, L Zhang, K Sun, K Li, Y Li, Q Zhang - Scientific reports, 2018 - nature.com
To improve the oral efficiency of exenatide, we prepared polyethylene glycol-poly (lactic-co-
glycolic acid)(PEG-PLGA) NPs modified with Fc (NPs-Fc) for exenatide oral delivery …
glycolic acid)(PEG-PLGA) NPs modified with Fc (NPs-Fc) for exenatide oral delivery …