Organization and regulation of gene transcription
P Cramer - Nature, 2019 - nature.com
The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
studies have elucidated mechanisms that govern the regulation of transcription by RNA …
Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes
One of the first biological machineries to be created seems to have been the ribosome.
Since then, organisms have dedicated great efforts to optimize this apparatus. The …
Since then, organisms have dedicated great efforts to optimize this apparatus. The …
Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases
The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …
[HTML][HTML] Cross-linking mass spectrometry (XL-MS): An emerging technology for interactomics and structural biology
Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …
and the assembly of multisubunit protein complexes that represent the functional …
50+ years of eukaryotic transcription: an expanding universe of factors and mechanisms
RG Roeder - Nature structural & molecular biology, 2019 - nature.com
The landmark 1969 discovery of nuclear RNA polymerases I, II and III in diverse eukaryotes
represented a major turning point in the field that, with subsequent elucidation of the distinct …
represented a major turning point in the field that, with subsequent elucidation of the distinct …
[HTML][HTML] Structural basis of mitochondrial transcription initiation
Transcription in human mitochondria is driven by a single-subunit, factor-dependent RNA
polymerase (mtRNAP). Despite its critical role in both expression and replication of the …
polymerase (mtRNAP). Despite its critical role in both expression and replication of the …
Structural basis of RNA polymerase III transcription initiation
RNA polymerase (Pol) III transcribes essential non-coding RNAs, including the entire pool of
transfer RNAs, the 5S ribosomal RNA and the U6 spliceosomal RNA, and is often …
transfer RNAs, the 5S ribosomal RNA and the U6 spliceosomal RNA, and is often …
Structure of nascent 5S RNPs at the crossroad between ribosome assembly and MDM2–p53 pathways
NM Castillo Duque de Estrada, M Thoms… - Nature Structural & …, 2023 - nature.com
The 5S ribonucleoprotein (RNP) is assembled from its three components (5S rRNA,
Rpl5/uL18 and Rpl11/uL5) before being incorporated into the pre-60S subunit. However …
Rpl5/uL18 and Rpl11/uL5) before being incorporated into the pre-60S subunit. However …
Structure of human RNA polymerase III
EP Ramsay, G Abascal-Palacios, JL Daiß… - Nature …, 2020 - nature.com
Abstract In eukaryotes, RNA Polymerase (Pol) III is specialized for the transcription of tRNAs
and other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan …
and other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan …
Molecular mechanism of promoter opening by RNA polymerase III
Abstract RNA polymerase III (Pol III) and transcription factor IIIB (TFIIIB) assemble together
on different promoter types to initiate the transcription of small, structured RNAs. Here we …
on different promoter types to initiate the transcription of small, structured RNAs. Here we …