Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
E Chirshev, KC Oberg, YJ Ioffe… - Clinical and translational …, 2019 - Springer
Abnormal regulation and expression of microRNAs (miRNAs) has been documented in
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …
The let-7 family of microRNAs
S Roush, FJ Slack - Trends in cell biology, 2008 - cell.com
The first two known microRNAs (miRNAs), lin-4 and let-7, were originally discovered in the
nematode Caenorhabditis elegans and control the timing of stem-cell division and …
nematode Caenorhabditis elegans and control the timing of stem-cell division and …
[HTML][HTML] MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling
Tumor cells metastasize to distant organs through genetic and epigenetic alterations,
including changes in microRNA (miR) expression. Here we find miR-22 triggers epithelial …
including changes in microRNA (miR) expression. Here we find miR-22 triggers epithelial …
Selective release of microRNA species from normal and malignant mammary epithelial cells
L Pigati, SCS Yaddanapudi, R Iyengar, DJ Kim… - PloS one, 2010 - journals.plos.org
MicroRNAs (miRNAs) in body fluids are candidate diagnostics for a variety of conditions and
diseases, including breast cancer. One premise for using extracellular miRNAs to diagnose …
diseases, including breast cancer. One premise for using extracellular miRNAs to diagnose …
The role of let-7 in cell differentiation and cancer
B Boyerinas, SM Park, A Hau… - Endocrine-related …, 2010 - erc.bioscientifica.com
MicroRNAs (miRNAs or miRs) are small noncoding RNAs capable of regulating gene
expression at the translational level. Current evidence suggests that a significant portion of …
expression at the translational level. Current evidence suggests that a significant portion of …
[HTML][HTML] GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression
Despite advances in our understanding of breast cancer, patients with metastatic disease
have poor prognoses. GATA3 is a transcription factor that specifies and maintains mammary …
have poor prognoses. GATA3 is a transcription factor that specifies and maintains mammary …
[HTML][HTML] A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment
Abstract miRNA populations, including mammalian homologues of lin-4 (mir-125) and let-7,
undergo a marked transition during stem-cell differentiation. Originally identified on the basis …
undergo a marked transition during stem-cell differentiation. Originally identified on the basis …
let-7 microRNAs in development, stem cells and cancer
I Büssing, FJ Slack, H Großhans - Trends in molecular medicine, 2008 - cell.com
MicroRNAs (miRNAs) are small noncoding RNAs,∼ 22 nucleotides in length, that repress
target messenger RNAs (mRNAs) through an antisense mechanism. The let-7 miRNA was …
target messenger RNAs (mRNAs) through an antisense mechanism. The let-7 miRNA was …
Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers
Aldehyde dehydrogenase isoform 1 (ALDH1) has been proved useful for the identification of
cancer stem cells. However, our knowledge of the expression and activity of ALDH1 in …
cancer stem cells. However, our knowledge of the expression and activity of ALDH1 in …
C-MYC inhibited ferroptosis and promoted immune evasion in ovarian cancer cells through NCOA4 mediated ferritin autophagy
Y Jin, J Qiu, X Lu, G Li - Cells, 2022 - mdpi.com
Objective: We aimed to construct the ferritin autophagy regulatory network and illustrate its
mechanism in ferroptosis, TME immunity and malignant phenotypes of ovarian cancer …
mechanism in ferroptosis, TME immunity and malignant phenotypes of ovarian cancer …