Targeting inflammation in atherosclerosis—from experimental insights to the clinic

O Soehnlein, P Libby - Nature reviews Drug discovery, 2021 - nature.com
Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

Clinical application of intermittent fasting for weight loss: progress and future directions

KA Varady, S Cienfuegos, M Ezpeleta… - Nature Reviews …, 2022 - nature.com
Intermittent fasting diets have become very popular in the past few years, as they can
produce clinically significant weight loss. These diets can be defined, in the simplest of …

Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial

XT Teong, K Liu, AD Vincent, J Bensalem, B Liu… - Nature Medicine, 2023 - nature.com
Intermittent fasting appears an equivalent alternative to calorie restriction (CR) to improve
health in humans. However, few trials have considered applying meal timing during the …

Intermittent fasting and metabolic health

I Vasim, CN Majeed, MD DeBoer - Nutrients, 2022 - mdpi.com
Given the ongoing strain that the obesity epidemic has placed on public health outcomes,
new and effective approaches to weight control are needed. One approach to improving …

Effects of intermittent fasting on health, aging, and disease

R De Cabo, MP Mattson - New England Journal of Medicine, 2019 - Mass Medical Soc
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a
6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to …

[PDF][PDF] Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes

EF Sutton, R Beyl, KS Early, WT Cefalu, E Ravussin… - Cell metabolism, 2018 - cell.com
Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether
these effects are due solely to weight loss. We conducted the first supervised controlled …

Effectiveness of early time-restricted eating for weight loss, fat loss, and cardiometabolic health in adults with obesity: a randomized clinical trial

H Jamshed, FL Steger, DR Bryan… - JAMA internal …, 2022 - jamanetwork.com
Importance It is unclear how effective intermittent fasting is for losing weight and body fat,
and the effects may depend on the timing of the eating window. This randomized trial …

Flipping the metabolic switch: understanding and applying the health benefits of fasting

SD Anton, K Moehl, WT Donahoo, K Marosi, SA Lee… - …, 2018 - Wiley Online Library
Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in
which no or few calories are consumed for time periods that can range from 12 hours to …

The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

SJ Hofer, D Carmona‐Gutierrez, MI Mueller… - EMBO Molecular …, 2022 - embopress.org
Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Intermittent and periodic fasting, longevity and disease

VD Longo, M Di Tano, MP Mattson, N Guidi - Nature aging, 2021 - nature.com
Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …