Asymmetric organocatalysis: an enabling technology for medicinal chemistry

B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

Recent advances in organocatalytic asymmetric multicomponent cascade reactions for enantioselective synthesis of spirooxindoles

Y Wang, AA Cobo, AK Franz - Organic Chemistry Frontiers, 2021 - pubs.rsc.org
Asymmetric catalytic multicomponent cascade reactions have become indispensable tools
for enantioselective construction of spirooxindoles. In recent years, a number of successful …

Challenges and opportunities in multicatalysis

S Martínez, L Veth, B Lainer, P Dydio - ACS Catalysis, 2021 - ACS Publications
Multicatalysis is an emerging field targeting the development of efficient catalytic
transformations to quickly convert relatively simple starting materials into more complex …

Visible light organic photoredox catalytic cascade reactions

GQ Xu, PF Xu - Chemical Communications, 2021 - pubs.rsc.org
Over the past years, impressive progress has been made in the development of organic
photoredox catalytic cascade reactions without the participation of expensive and toxic …

Photo‐biocatalytic cascades: combining chemical and enzymatic transformations fueled by light

FF Özgen, ME Runda, S Schmidt - ChemBioChem, 2021 - Wiley Online Library
In the field of green chemistry, light–an attractive natural agent–has received particular
attention for driving biocatalytic reactions. Moreover, the implementation of light to drive …

Recent developments in next generation (S)-proline-derived chiral organocatalysts

E Juaristi - Tetrahedron, 2021 - Elsevier
In the area of asymmetric organocatalysis, significant effort has been dedicated during the
last decade to improve the performance of emblematic catalysts such as proline, as well as …

Revealing the similarities of α, β‐unsaturated iminiums and acylazoliums in organocatalysis

A Ghosh, AT Biju - Angewandte Chemie International Edition, 2021 - Wiley Online Library
The secondary amine‐catalyzed reactions proceeding via α, β‐unsaturated iminiums and
the N‐heterocyclic carbene (NHC)‐catalyzed transformations taking place via α, β …

[HTML][HTML] Recent developments in one-pot stepwise synthesis (OPSS) of small molecules

X Ma, W Zhang - Iscience, 2022 - cell.com
One-pot synthesis is an active topic in organic chemistry due to its intrinsic advantages of
simple operation, high mass efficiency, low cost, and less amount of waste disposal. Among …

[HTML][HTML] Iodonium salts as efficient iodine (III)-based noncovalent organocatalysts for Knorr-type reactions

SN Yunusova, AS Novikov, NS Soldatova, MA Vovk… - RSC …, 2021 - pubs.rsc.org
Hypervalent iodine (III)-derivatives display higher catalytic activity than other aliphatic and
aromatic iodine (I)–or bromine (I)-containing substrates for a Knorr-type reaction of N-acetyl …

[HTML][HTML] Chiral thioureas—preparation and significance in asymmetric synthesis and medicinal chemistry

F Steppeler, D Iwan, E Wojaczyńska, J Wojaczyński - Molecules, 2020 - mdpi.com
For almost 20 years, thioureas have been experiencing a renaissance of interest with the
emerged development of asymmetric organocatalysts. Due to their relatively high acidity and …