Skin, the largest organ of the human body, is organized into an elaborate layered structure
consisting mainly of the outermost epidermis and the underlying dermis. A subcutaneous …

It is clear that a number of host-cell factors facilitate virus replication and, conversely, a
number of other factors possess inherent antiviral activity. Research, particularly over the …

Tracheal and esophageal disorders are prevalent in humans and difficult to accurately
model in mice. We therefore established a three-dimensional organoid model of esophageal …

Introduction: Hematopoietic cell transplantation for Fanconi Anemia (FA) has improved
dramatically over the past 40 years. With an enhanced understanding of the intrinsic DNA …

In recent years, oncologists have begun to conclude that chemotherapy has reached a
plateau of efficacy as a primary treatment modality, even if toxicity can be effectively …

High-risk HPV E6 and E7 oncoproteins cooperate to subvert critical host cell cycle
checkpoint control mechanisms in order to promote viral genome replication. This results not …

High-risk human papillomaviruses (HPVs) are the causative agents of cervical and other
genital cancers. In addition, HPV infections are associated with the development of many …

Objectives/Hypothesis To describe the management and outcomes of Fanconi anemia (FA)
patients with head and neck squamous cell carcinoma. Study Design Cohort study. Methods …

Fanconi anemia (FA) is a rare genetic disorder characterized by an increased susceptibility
to squamous cell cancers. Fifteen FA genes are known, and the encoded proteins cooperate …

In general, the interplay among viruses and DNA damage repair (DDR) pathways can be
divided based on whether the interaction promotes or inhibits the viral lifecycle. The …