Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …
tissue and cell functions and significant increases in the risks of various aging-related …
Measuring biological age using omics data
Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …
related diseases and increase healthspan have suggested targeting the ageing process …
[HTML][HTML] Nutrition, longevity and disease: From molecular mechanisms to interventions
VD Longo, RM Anderson - Cell, 2022 - cell.com
Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …
frequency of fasting periods, affects the time span in which health and functional capacity …
DunedinPACE, a DNA methylation biomarker of the pace of aging
Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …
DNA methylation-based predictors of health: applications and statistical considerations
DNA methylation data have become a valuable source of information for biomarker
development, because, unlike static genetic risk estimates, DNA methylation varies …
development, because, unlike static genetic risk estimates, DNA methylation varies …
Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality
Biomarkers developed from DNA methylation (DNAm) data are of growing interest as
predictors of health outcomes and mortality in older populations. However, it is unknown …
predictors of health outcomes and mortality in older populations. However, it is unknown …
Biological age is increased by stress and restored upon recovery
Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …
The multiple roles of life stress in metabolic disorders
The activation of stress-related neuroendocrine systems helps to maintain homeostasis, but
excessive stress can damage body functions. We review current evidence from basic …
excessive stress can damage body functions. We review current evidence from basic …
Disparities in the pace of biological aging among midlife adults of the same chronological age have implications for future frailty risk and policy
Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …
midlife, but the implications of this variation are poorly understood. We tested associations …
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
AT Higgins-Chen, KL Thrush, Y Wang, CJ Minteer… - Nature aging, 2022 - nature.com
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …
but this data can be surprisingly unreliable. Here we show that technical noise produces …