Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer

K Polom, L Marano, D Marrelli, R De Luca… - Journal of British …, 2018 - academic.oup.com
Background Several associations between microsatellite instability (MSI) and other
clinicopathological factors have been reported in gastric cancer, but the results have been …

Lauren classification and individualized chemotherapy in gastric cancer

J Ma, H Shen, L Kapesa, S Zeng - Oncology letters, 2016 - spandidos-publications.com
Gastric cancer is one of the most common malignancies worldwide. During the last 50 years,
the histological classification of gastric carcinoma has been largely based on Lauren's …

From tumor immunology to immunotherapy in gastric and esophageal cancer

D Vrána, M Matzenauer, Č Neoral, R Aujeský… - International journal of …, 2018 - mdpi.com
Esophageal and gastric cancers represent tumors with poor prognosis. Unfortunately,
radiotherapy, chemotherapy, and targeted therapy have made only limited progress in …

PD-L1: Biological mechanism, function, and immunotherapy in gastric cancer

Y Zhang, Y Yang, Y Chen, W Lin, X Chen, J Liu… - Frontiers in …, 2022 - frontiersin.org
Gastric cancer (GC) is one of the main causes of cancer incidence rate and mortality
worldwide. As the main breakthrough direction, the application of immune checkpoint …

Heterogeneity in gastric cancer: from pure morphology to molecular classifications

I Gullo, F Carneiro, C Oliveira, GM Almeida - Pathobiology, 2018 - karger.com
Gastric cancer (GC) represents a global health concern. Despite advances in prevention,
diagnosis, and therapy, GC is still the third leading cause of cancer mortality worldwide, with …

Elevated risk of prostate cancer among men with Lynch syndrome

VM Raymond, B Mukherjee, F Wang… - Journal of clinical …, 2013 - ascopubs.org
Purpose Prostate cancer has been described as a component tumor of Lynch syndrome
(LS), with tumors obtained from mutation carriers demonstrating the DNA mismatch repair …

Diagnosis of Lynch syndrome and strategies to distinguish Lynch-related tumors from sporadic MSI/dMMR tumors

J Leclerc, C Vermaut, MP Buisine - Cancers, 2021 - mdpi.com
Simple Summary Microsatellite instability (MSI) is a hallmark of Lynch syndrome (LS)-related
tumors but is not specific, as most of MSI/mismatch repair-deficient (dMMR) tumors are …

Clinicopathologic characteristics of microsatellite instable gastric carcinomas revisited: urgent need for standardization

M Mathiak, VS Warneke, HM Behrens… - Applied …, 2017 - journals.lww.com
Microsatellite instable gastric cancer (MSI-GC) is a specific molecular subtype of GC. We
studied the phenotypes, genotypes, and clinicopathologic characteristics of MSI-GC in a …

The benefit of microsatellite instability is attenuated by chemotherapy in stage II and stage III gastric cancer: results from a large cohort with subgroup analyses

SY Kim, YY Choi, JY An, HB Shin, A Jo… - … Journal of Cancer, 2015 - Wiley Online Library
We previously reported that the prognosis of microsatellite instability high (MSI‐H) gastric
cancer is similar to that of MSI‐low/microsatellite stable (MSI‐L/MSS) gastric cancer. The …

Influence of microRNAs and long non-coding RNAs in cancer chemoresistance

D Ayers, J Vandesompele - Genes, 2017 - mdpi.com
Innate and acquired chemoresistance exhibited by most tumours exposed to conventional
chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such …