Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis
Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …
Osteoarthritis as a disease of the cartilage pericellular matrix
Osteoarthritis is a painful joint disease characterized by progressive degeneration of the
articular cartilage as well as associated changes to the subchondral bone, synovium, and …
articular cartilage as well as associated changes to the subchondral bone, synovium, and …
Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis
Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any
disease-modifying therapies [AM Valdes, TD Spector, Nat. Rev. Rheumatol. 7, 23–32 …
disease-modifying therapies [AM Valdes, TD Spector, Nat. Rev. Rheumatol. 7, 23–32 …
[HTML][HTML] Senescence in osteoarthritis: from mechanism to potential treatment
Y Liu, Z Zhang, T Li, H Xu, H Zhang - Arthritis Research & Therapy, 2022 - Springer
Osteoarthritis (OA) is an age-related cartilage degenerative disease, and chondrocyte
senescence has been extensively studied in recent years. Increased numbers of senescent …
senescence has been extensively studied in recent years. Increased numbers of senescent …
TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
Regulation of pain and itch by TRP channels
Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …
pain perception. In this review, we discuss important experimental evidence involving some …
Piezo1 is a mechanosensor channel in central nervous system capillaries
Capillaries are equipped to sense neurovascular coupling agents released onto the outer
wall of a capillary, translating these external signals into electrical/Ca2+ changes that play a …
wall of a capillary, translating these external signals into electrical/Ca2+ changes that play a …
Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis
Mechanical stress plays a critical role in cartilage development and homoeostasis.
Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs …
Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs …
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage
Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular
cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in …
cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in …
Membrane stretch as the mechanism of activation of PIEZO1 ion channels in chondrocytes
A Savadipour, RJ Nims, N Rashidi… - Proceedings of the …, 2023 - National Acad Sciences
Osteoarthritis is a chronic disease that can be initiated by altered joint loading or injury of the
cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce …
cartilage. The mechanically sensitive PIEZO ion channels have been shown to transduce …