Bioinformatics methods for mass spectrometry-based proteomics data analysis
Recent advances in mass spectrometry (MS)-based proteomics have enabled tremendous
progress in the understanding of cellular mechanisms, disease progression, and the …
progress in the understanding of cellular mechanisms, disease progression, and the …
Analytical methods in untargeted metabolomics: state of the art in 2015
Metabolomics comprises the methods and techniques that are used to measure the small
molecule composition of biofluids and tissues, and is actually one of the most rapidly …
molecule composition of biofluids and tissues, and is actually one of the most rapidly …
[HTML][HTML] Deep multilayer brain proteomics identifies molecular networks in Alzheimer's disease progression
Alzheimer's disease (AD) displays a long asymptomatic stage before dementia. We
characterize AD stage-associated molecular networks by profiling 14,513 proteins and …
characterize AD stage-associated molecular networks by profiling 14,513 proteins and …
Cancer metabolites: promising biomarkers for cancer liquid biopsy
Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular
metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of …
metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of …
Statistical strategies for avoiding false discoveries in metabolomics and related experiments
DI Broadhurst, DB Kell - Metabolomics, 2006 - Springer
Many metabolomics, and other high-content or high-throughput, experiments are set up
such that the primary aim is the discovery of biomarker metabolites that can discriminate …
such that the primary aim is the discovery of biomarker metabolites that can discriminate …
statTarget: A streamlined tool for signal drift correction and interpretations of quantitative mass spectrometry-based omics data
H Luan, F Ji, Y Chen, Z Cai - Analytica chimica acta, 2018 - Elsevier
Large-scale quantitative mass spectrometry-based metabolomics and proteomics study
requires the long-term analysis of multiple batches of biological samples, which often …
requires the long-term analysis of multiple batches of biological samples, which often …
Role of spectral counting in quantitative proteomics
DH Lundgren, SI Hwang, L Wu… - Expert review of …, 2010 - Taylor & Francis
Spectral count, defined as the total number of spectra identified for a protein, has gained
acceptance as a practical, label-free, semiquantitative measure of protein abundance in …
acceptance as a practical, label-free, semiquantitative measure of protein abundance in …
A simple implementation of a normal mixture approach to differential gene expression in multiclass microarrays
GJ McLachlan, RW Bean, LBT Jones - Bioinformatics, 2006 - academic.oup.com
Motivation: An important problem in microarray experiments is the detection of genes that
are differentially expressed in a given number of classes. We provide a straightforward and …
are differentially expressed in a given number of classes. We provide a straightforward and …
Disturbance and restoration of soil microbial communities after in-situ thermal desorption in a chlorinated hydrocarbon contaminated site
J Shentu, Q Chen, Y Cui, Y Wang, L Lu, Y Long… - Journal of Hazardous …, 2023 - Elsevier
Thermal desorption technology has been widely used for the remediation of organic
contaminated soil, but the heating process may alter the soil properties and its safety …
contaminated soil, but the heating process may alter the soil properties and its safety …
Habitat heterogeneity induced by pyrogenic organic matter in wildfire-perturbed soils mediates bacterial community assembly processes
Although pyrogenic organic matter (PyOM) generated during wildfires plays a critical role in
post-fire ecosystem recovery, the specific mechanisms by which PyOM controls soil …
post-fire ecosystem recovery, the specific mechanisms by which PyOM controls soil …