Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which
the viral genome became embedded as a dormant regulatory element within the host …

The immune system and the kidneys are closely related. Immune components mediate
acute kidney disease and are crucial to the progression of chronic kidney disease. Beyond …

Different innate immune pathways converge to Stimulator of interferon genes (STING) and
trigger type I interferon responses after recognition of abnormal nucleic acids in the cells …

Background Individuals with type 2 diabetes (T2D) face an increased mortality risk, not fully
captured by canonical risk factors. Biological age estimation through DNA methylation …

Reactivation of retroelements in the human genome has been linked to aging. However,
whether the epigenetic state of specific retroelements can predict chronological age remains …

Endogenous double-stranded RNA has emerged as a potent stimulator of innate immunity.
Under physiological conditions, endogenous dsRNA is maintained in the cell nucleus or the …

Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease with no
cure. Human endogenous retroviruses (HERVs) have been implicated in its pathogenesis …

Coronavirus disease 2019 (COVID-19) induces respiratory dysfunction as well as kidney
injury. Although the kidney is considered a target organ of severe acute respiratory …

In-situ renal tissue engineering is promising yet challenging for renal injury repair and
regeneration due to the highly vascularized structure of renal tissue and complex high …

The field of nephrology has recently directed a considerable amount of attention towards the
stimulator of interferon genes (STING) molecule since it appears to be a potent driver of …