Influence of the tumor microenvironment on NK cell function in solid tumors
Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …
host immune responses against infection and tumor growth. These cells have a powerful …
Leveraging NKG2D ligands in immuno-oncology
Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened
new avenues towards the development of novel assets to achieve durable immune control …
new avenues towards the development of novel assets to achieve durable immune control …
NKG2D and its ligands in cancer
P Dhar, JD Wu - Current opinion in immunology, 2018 - Elsevier
Highlights•NKG2D pathway is significant for both innate and adoptive tumor
immunity.•Soluble and membrane-bound NKG2D ligands confer opposite role in tumor …
immunity.•Soluble and membrane-bound NKG2D ligands confer opposite role in tumor …
[HTML][HTML] Role of NKG2D and its ligands in cancer immunotherapy
H Liu, S Wang, J Xin, J Wang, C Yao… - American journal of …, 2019 - ncbi.nlm.nih.gov
The activating receptor natural killer group 2, member D (NKG2D) is involved in both innate
and adaptive immunities, and functions as a “master switch” in determining the activation …
and adaptive immunities, and functions as a “master switch” in determining the activation …
Past, current, and future of immunotherapies for prostate cancer
AN Boettcher, A Usman, A Morgans… - Frontiers in …, 2019 - frontiersin.org
Prostate cancer (PCa) is the most common cancer in men, and the second leading cause of
cancer related death in men in Western countries. The standard therapy for metastatic PCa …
cancer related death in men in Western countries. The standard therapy for metastatic PCa …
NK cell-based therapeutics for lung cancer
AG Pockley, P Vaupel, G Multhoff - Expert opinion on biological …, 2020 - Taylor & Francis
Introduction: Lung cancer is a devastating disease with poor overall survival. Despite
significant advances in the treatment of lung cancers using radiochemotherapy, targeted …
significant advances in the treatment of lung cancers using radiochemotherapy, targeted …
The paradoxical role of NKG2D in cancer immunity
The activating receptor NKG2D and its ligands are recognized as a potent immune axis that
controls tumor growth and microbial infections. With regards to cancer surveillance, various …
controls tumor growth and microbial infections. With regards to cancer surveillance, various …
Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization
S Chen, H Zhu, Y Jounaidi - Signal Transduction and Targeted Therapy, 2024 - nature.com
Natural killer (NK) cells, initially identified for their rapid virus-infected and leukemia cell
killing and tumor destruction, are pivotal in immunity. They exhibit multifaceted roles in …
killing and tumor destruction, are pivotal in immunity. They exhibit multifaceted roles in …
Exploiting NK cell surveillance pathways for cancer therapy
Natural killer (NK) cells can evoke potent anti-tumour activity. This function is largely
mediated through a battery of specialised cell-surface receptors which probe the tissue …
mediated through a battery of specialised cell-surface receptors which probe the tissue …
Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 …
Background Melanoma patients who have detectable serum soluble NKG2D ligands either
at the baseline or post-treatment of PD1/PDL1 blockade exhibit poor overall survival. Among …
at the baseline or post-treatment of PD1/PDL1 blockade exhibit poor overall survival. Among …